PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES

Specific antibody formation has been elicited in vitro following antigenic stimulation by either sheep (in a total of 472 of 875 cultures) or chick erythrocytes (in 65 of 135 cultures tested). The response was manifested by mouse spleen and lymph node explants whereas thymus cultures were inactive....

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Detalles Bibliográficos
Autores principales: Globerson, Amiela, Auerbach, Robert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138273/
https://www.ncbi.nlm.nih.gov/pubmed/5926296
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author Globerson, Amiela
Auerbach, Robert
author_facet Globerson, Amiela
Auerbach, Robert
author_sort Globerson, Amiela
collection PubMed
description Specific antibody formation has been elicited in vitro following antigenic stimulation by either sheep (in a total of 472 of 875 cultures) or chick erythrocytes (in 65 of 135 cultures tested). The response was manifested by mouse spleen and lymph node explants whereas thymus cultures were inactive. The reaction has been characterized as a primary immune response in view of its kinetics as compared to defined primary and secondary responses, the effect of 2-mercaptoethanol on the antibodies formed, its subject to puromycin inhibition and its sensitivity to X-irradiation. Histological studies revealed preservation of the lymphoid cell populations throughout the entire experimental period.
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spelling pubmed-21382732008-04-17 PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES Globerson, Amiela Auerbach, Robert J Exp Med Article Specific antibody formation has been elicited in vitro following antigenic stimulation by either sheep (in a total of 472 of 875 cultures) or chick erythrocytes (in 65 of 135 cultures tested). The response was manifested by mouse spleen and lymph node explants whereas thymus cultures were inactive. The reaction has been characterized as a primary immune response in view of its kinetics as compared to defined primary and secondary responses, the effect of 2-mercaptoethanol on the antibodies formed, its subject to puromycin inhibition and its sensitivity to X-irradiation. Histological studies revealed preservation of the lymphoid cell populations throughout the entire experimental period. The Rockefeller University Press 1966-10-31 /pmc/articles/PMC2138273/ /pubmed/5926296 Text en Copyright © 1966 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Globerson, Amiela
Auerbach, Robert
PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES
title PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES
title_full PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES
title_fullStr PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES
title_full_unstemmed PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES
title_short PRIMARY ANTIBODY RESPONSE IN ORGAN CULTURES
title_sort primary antibody response in organ cultures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138273/
https://www.ncbi.nlm.nih.gov/pubmed/5926296
work_keys_str_mv AT globersonamiela primaryantibodyresponseinorgancultures
AT auerbachrobert primaryantibodyresponseinorgancultures

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