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IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE
Hemolytic disease characterized by slight anemia, reticulocytosis, hemosiderosis, extramedullary hematopoiesis, and positive indirect antiglobulin (Coombs') tests and renal disease with proteinuria, hypoalbuminemia, and glomerular lesions were produced in Swiss mice by neonatal intraperitoneal...
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1967
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138299/ https://www.ncbi.nlm.nih.gov/pubmed/6027647 |
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author | Mellors, Robert C. Huang, Chen Ya |
author_facet | Mellors, Robert C. Huang, Chen Ya |
author_sort | Mellors, Robert C. |
collection | PubMed |
description | Hemolytic disease characterized by slight anemia, reticulocytosis, hemosiderosis, extramedullary hematopoiesis, and positive indirect antiglobulin (Coombs') tests and renal disease with proteinuria, hypoalbuminemia, and glomerular lesions were produced in Swiss mice by neonatal intraperitoneal inoculation of cell-free filtrates prepared from the spleens of old NZB/Bl mice. Lymphoid cell and plasma cell hyperplasia as well as hypergammaglobulinemia occurred in some of these inoculated mice. Type "C" murine oncogenic virus-like particles, indistinguishable from those previously described (1), were shown by electron microscopic study to be present in distinctive locations, notably in the basal foldings of convoluted tubules in the kidneys of a newborn NZB/Bl mouse, old NZB/Bl mice, a CBA x NZB F(1) hybrid mouse, and a Swiss mouse inoculated with NZB/Bl spleen cell-free filtrate. These observations point to two (perhaps related) circumstances which may be requisites for the pathogenic action of this newly discovered virus within and outside the strain NZB: infection of newborn, or infant, mice; persistent, possibly tolerant, infection of adult mice. |
format | Text |
id | pubmed-2138299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1967 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21382992008-04-17 IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE Mellors, Robert C. Huang, Chen Ya J Exp Med Article Hemolytic disease characterized by slight anemia, reticulocytosis, hemosiderosis, extramedullary hematopoiesis, and positive indirect antiglobulin (Coombs') tests and renal disease with proteinuria, hypoalbuminemia, and glomerular lesions were produced in Swiss mice by neonatal intraperitoneal inoculation of cell-free filtrates prepared from the spleens of old NZB/Bl mice. Lymphoid cell and plasma cell hyperplasia as well as hypergammaglobulinemia occurred in some of these inoculated mice. Type "C" murine oncogenic virus-like particles, indistinguishable from those previously described (1), were shown by electron microscopic study to be present in distinctive locations, notably in the basal foldings of convoluted tubules in the kidneys of a newborn NZB/Bl mouse, old NZB/Bl mice, a CBA x NZB F(1) hybrid mouse, and a Swiss mouse inoculated with NZB/Bl spleen cell-free filtrate. These observations point to two (perhaps related) circumstances which may be requisites for the pathogenic action of this newly discovered virus within and outside the strain NZB: infection of newborn, or infant, mice; persistent, possibly tolerant, infection of adult mice. The Rockefeller University Press 1967-07-01 /pmc/articles/PMC2138299/ /pubmed/6027647 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Mellors, Robert C. Huang, Chen Ya IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE |
title | IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE |
title_full | IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE |
title_fullStr | IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE |
title_full_unstemmed | IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE |
title_short | IMMUNOPATHOLOGY OF NZB/BL MICE : VI. VIRUS SEPARABLE FROM SPLEEN AND PATHOGENIC FOR SWISS MICE |
title_sort | immunopathology of nzb/bl mice : vi. virus separable from spleen and pathogenic for swiss mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138299/ https://www.ncbi.nlm.nih.gov/pubmed/6027647 |
work_keys_str_mv | AT mellorsrobertc immunopathologyofnzbblmicevivirusseparablefromspleenandpathogenicforswissmice AT huangchenya immunopathologyofnzbblmicevivirusseparablefromspleenandpathogenicforswissmice |