STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE

In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the...

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Detalles Bibliográficos
Autores principales: Brody, Neil I., Walker, J. Geoffrey, Siskind, Gregory W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138300/
https://www.ncbi.nlm.nih.gov/pubmed/4165502
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author Brody, Neil I.
Walker, J. Geoffrey
Siskind, Gregory W.
author_facet Brody, Neil I.
Walker, J. Geoffrey
Siskind, Gregory W.
author_sort Brody, Neil I.
collection PubMed
description In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.
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spelling pubmed-21383002008-04-17 STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE Brody, Neil I. Walker, J. Geoffrey Siskind, Gregory W. J Exp Med Article In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation. The Rockefeller University Press 1967-07-01 /pmc/articles/PMC2138300/ /pubmed/4165502 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Brody, Neil I.
Walker, J. Geoffrey
Siskind, Gregory W.
STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE
title STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE
title_full STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE
title_fullStr STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE
title_full_unstemmed STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE
title_short STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS : INTERACTION OF ANTIGENIC COMPETITION AND SUPPRESSION OF ANTIBODY FORMATION BY PASSIVE ANTIBODY ON THE IMMUNE RESPONSE
title_sort studies on the control of antibody synthesis : interaction of antigenic competition and suppression of antibody formation by passive antibody on the immune response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138300/
https://www.ncbi.nlm.nih.gov/pubmed/4165502
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AT siskindgregoryw studiesonthecontrolofantibodysynthesisinteractionofantigeniccompetitionandsuppressionofantibodyformationbypassiveantibodyontheimmuneresponse

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