STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES

Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophag...

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Detalles Bibliográficos
Autores principales: Hahn, Helmut H., Char, David C., Postel, Wilfred B., Wood, W. Barry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138324/
https://www.ncbi.nlm.nih.gov/pubmed/6028492
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author Hahn, Helmut H.
Char, David C.
Postel, Wilfred B.
Wood, W. Barry
author_facet Hahn, Helmut H.
Char, David C.
Postel, Wilfred B.
Wood, W. Barry
author_sort Hahn, Helmut H.
collection PubMed
description Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophages is explained, and the relevance of macrophage pyrogen to fevers of agranulocytosis and other diseases, in which mononuclear rather than granulocytic exudates predominate, is discussed.
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spelling pubmed-21383242008-04-17 STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES Hahn, Helmut H. Char, David C. Postel, Wilfred B. Wood, W. Barry J Exp Med Article Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophages is explained, and the relevance of macrophage pyrogen to fevers of agranulocytosis and other diseases, in which mononuclear rather than granulocytic exudates predominate, is discussed. The Rockefeller University Press 1967-08-01 /pmc/articles/PMC2138324/ /pubmed/6028492 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hahn, Helmut H.
Char, David C.
Postel, Wilfred B.
Wood, W. Barry
STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES
title STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES
title_full STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES
title_fullStr STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES
title_full_unstemmed STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES
title_short STUDIES ON THE PATHOGENESIS OF FEVER : XV. THE PRODUCTION OF ENDOGENOUS PYROGEN BY PERITONEAL MACROPHAGES
title_sort studies on the pathogenesis of fever : xv. the production of endogenous pyrogen by peritoneal macrophages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138324/
https://www.ncbi.nlm.nih.gov/pubmed/6028492
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