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EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS
Rabbits immunized to different heterologous renal antigens developed antibodies some of which are fixed to their own glomeruli (autoantibodies). These autoantibodies, reacting with the host's kidneys, were directed to those antigenic determinants which were present in identical or cross-reactiv...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1967
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138345/ https://www.ncbi.nlm.nih.gov/pubmed/5334542 |
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author | Unanue, Emil R. Dixon, Frank J. |
author_facet | Unanue, Emil R. Dixon, Frank J. |
author_sort | Unanue, Emil R. |
collection | PubMed |
description | Rabbits immunized to different heterologous renal antigens developed antibodies some of which are fixed to their own glomeruli (autoantibodies). These autoantibodies, reacting with the host's kidneys, were directed to those antigenic determinants which were present in identical or cross-reactive form in both the immunizing antigen and the kidneys of the host. Glomerulonephritis developed in some of the rabbits immunized to heterologous mammalian kidneys, but in none of those immunized to nonmammalian kidneys. The development of glomerulonephritis in the immunized rabbits appears to depend upon two factors: (a) the amount of autoantikidney antibody made to the common renal antigens; and (b) the quantity of the common antigens available in the host's kidneys. An amount of common antigen sufficient to fix a nephritogenic amount of antibody is essential for the development of disease. |
format | Text |
id | pubmed-2138345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1967 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21383452008-04-17 EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS Unanue, Emil R. Dixon, Frank J. J Exp Med Article Rabbits immunized to different heterologous renal antigens developed antibodies some of which are fixed to their own glomeruli (autoantibodies). These autoantibodies, reacting with the host's kidneys, were directed to those antigenic determinants which were present in identical or cross-reactive form in both the immunizing antigen and the kidneys of the host. Glomerulonephritis developed in some of the rabbits immunized to heterologous mammalian kidneys, but in none of those immunized to nonmammalian kidneys. The development of glomerulonephritis in the immunized rabbits appears to depend upon two factors: (a) the amount of autoantikidney antibody made to the common renal antigens; and (b) the quantity of the common antigens available in the host's kidneys. An amount of common antigen sufficient to fix a nephritogenic amount of antibody is essential for the development of disease. The Rockefeller University Press 1967-01-01 /pmc/articles/PMC2138345/ /pubmed/5334542 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Unanue, Emil R. Dixon, Frank J. EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS |
title | EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS |
title_full | EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS |
title_fullStr | EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS |
title_full_unstemmed | EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS |
title_short | EXPERIMENTAL ALLERGIC GLOMERULONEPHRITIS INDUCED IN THE RABBIT WITH HETEROLOGOUS RENAL ANTIGENS |
title_sort | experimental allergic glomerulonephritis induced in the rabbit with heterologous renal antigens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138345/ https://www.ncbi.nlm.nih.gov/pubmed/5334542 |
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