STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS

The addition of sheep antisera to rabbit IgG or to rabbit IgG subunits (L chain, H chain, Fab piece, Fc piece) to in vitro cultures of rabbit peripheral lymphocytes may induce up to 80–90% of the small lymphocytes to transform into immature "blast" cells. As many as 1 x 10(7) molecules of...

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Detalles Bibliográficos
Autor principal: Sell, Stewart
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138360/
https://www.ncbi.nlm.nih.gov/pubmed/4163709
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author Sell, Stewart
author_facet Sell, Stewart
author_sort Sell, Stewart
collection PubMed
description The addition of sheep antisera to rabbit IgG or to rabbit IgG subunits (L chain, H chain, Fab piece, Fc piece) to in vitro cultures of rabbit peripheral lymphocytes may induce up to 80–90% of the small lymphocytes to transform into immature "blast" cells. As many as 1 x 10(7) molecules of antibody may be required to stimulate each cell. It is concluded that each peripheral lymphocyte carries the antigenic specificities of the entire IgG molecule and thus could carry, and may produce specific antibody molecules. Such a conclusion supports the theory that the small lymphocyte may be the site of specific recognition of antigens in the primary response.
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spelling pubmed-21383602008-04-17 STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS Sell, Stewart J Exp Med Article The addition of sheep antisera to rabbit IgG or to rabbit IgG subunits (L chain, H chain, Fab piece, Fc piece) to in vitro cultures of rabbit peripheral lymphocytes may induce up to 80–90% of the small lymphocytes to transform into immature "blast" cells. As many as 1 x 10(7) molecules of antibody may be required to stimulate each cell. It is concluded that each peripheral lymphocyte carries the antigenic specificities of the entire IgG molecule and thus could carry, and may produce specific antibody molecules. Such a conclusion supports the theory that the small lymphocyte may be the site of specific recognition of antigens in the primary response. The Rockefeller University Press 1967-01-31 /pmc/articles/PMC2138360/ /pubmed/4163709 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sell, Stewart
STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS
title STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS
title_full STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS
title_fullStr STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS
title_full_unstemmed STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS
title_short STUDIES ON RABBIT LYMPHOCYTES IN VITRO : V. THE INDUCTION OF BLAST TRANSFORMATION WITH SHEEP ANTISERA TO RABBIT IGG SUBUNITS
title_sort studies on rabbit lymphocytes in vitro : v. the induction of blast transformation with sheep antisera to rabbit igg subunits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138360/
https://www.ncbi.nlm.nih.gov/pubmed/4163709
work_keys_str_mv AT sellstewart studiesonrabbitlymphocytesinvitrovtheinductionofblasttransformationwithsheepantiseratorabbitiggsubunits

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