FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION

Data pertaining to the endogenous mouse spleen colony system, 10 days postirradiation, are presented. The D(o) for visible colonies is 78 R, while that for 6 hr iron uptake over a range of 600–800 R is 50 R. The D(o) for spleen weight is 196 R and that for IUdR uptake is 193 R. These measurements in...

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Autores principales: Marsh, John C., Boggs, Dane R., Bishop, Carter R., Chervenick, Paul A., Cartwright, George E., Wintrobe, Maxwell M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138407/
https://www.ncbi.nlm.nih.gov/pubmed/6062002
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author Marsh, John C.
Boggs, Dane R.
Bishop, Carter R.
Chervenick, Paul A.
Cartwright, George E.
Wintrobe, Maxwell M.
author_facet Marsh, John C.
Boggs, Dane R.
Bishop, Carter R.
Chervenick, Paul A.
Cartwright, George E.
Wintrobe, Maxwell M.
author_sort Marsh, John C.
collection PubMed
description Data pertaining to the endogenous mouse spleen colony system, 10 days postirradiation, are presented. The D(o) for visible colonies is 78 R, while that for 6 hr iron uptake over a range of 600–800 R is 50 R. The D(o) for spleen weight is 196 R and that for IUdR uptake is 193 R. These measurements increase with the age of the mouse. Hypertransfusion decreases spleen iron uptake and colony number. DF-(32)P and sodium sulfate-(35)S are not useful indicators of splenic hematopoiesis in this system. Visible hematopoietic colonies in the spleen are not produced by vinblastine, nitrogen mustard, methotrexate, or cyclophosphamide.
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spelling pubmed-21384072008-04-17 FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION Marsh, John C. Boggs, Dane R. Bishop, Carter R. Chervenick, Paul A. Cartwright, George E. Wintrobe, Maxwell M. J Exp Med Article Data pertaining to the endogenous mouse spleen colony system, 10 days postirradiation, are presented. The D(o) for visible colonies is 78 R, while that for 6 hr iron uptake over a range of 600–800 R is 50 R. The D(o) for spleen weight is 196 R and that for IUdR uptake is 193 R. These measurements increase with the age of the mouse. Hypertransfusion decreases spleen iron uptake and colony number. DF-(32)P and sodium sulfate-(35)S are not useful indicators of splenic hematopoiesis in this system. Visible hematopoietic colonies in the spleen are not produced by vinblastine, nitrogen mustard, methotrexate, or cyclophosphamide. The Rockefeller University Press 1967-10-31 /pmc/articles/PMC2138407/ /pubmed/6062002 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Marsh, John C.
Boggs, Dane R.
Bishop, Carter R.
Chervenick, Paul A.
Cartwright, George E.
Wintrobe, Maxwell M.
FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION
title FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION
title_full FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION
title_fullStr FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION
title_full_unstemmed FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION
title_short FACTORS INFLUENCING HEMATOPOIETIC SPLEEN COLONY FORMATION IN IRRADIATED MICE : I. THE NORMAL PATTERN OF ENDOGENOUS COLONY FORMATION
title_sort factors influencing hematopoietic spleen colony formation in irradiated mice : i. the normal pattern of endogenous colony formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138407/
https://www.ncbi.nlm.nih.gov/pubmed/6062002
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