IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE

Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high...

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Detalles Bibliográficos
Autores principales: Hirsch, Martin S., Murphy, Frederick A., Hicklin, Martin D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138472/
https://www.ncbi.nlm.nih.gov/pubmed/4868581
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author Hirsch, Martin S.
Murphy, Frederick A.
Hicklin, Martin D.
author_facet Hirsch, Martin S.
Murphy, Frederick A.
Hicklin, Martin D.
author_sort Hirsch, Martin S.
collection PubMed
description Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.
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spelling pubmed-21384722008-04-17 IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE Hirsch, Martin S. Murphy, Frederick A. Hicklin, Martin D. J Exp Med Article Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs. The Rockefeller University Press 1968-03-31 /pmc/articles/PMC2138472/ /pubmed/4868581 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hirsch, Martin S.
Murphy, Frederick A.
Hicklin, Martin D.
IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE
title IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE
title_full IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE
title_fullStr IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE
title_full_unstemmed IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE
title_short IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE
title_sort immunopathology of lymphocytic choriomeningitis virus infection of newborn mice : antithymocyte serum effects on glomerulonephrotis and wasting disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138472/
https://www.ncbi.nlm.nih.gov/pubmed/4868581
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AT murphyfredericka immunopathologyoflymphocyticchoriomeningitisvirusinfectionofnewbornmiceantithymocyteserumeffectsonglomerulonephrotisandwastingdisease
AT hicklinmartind immunopathologyoflymphocyticchoriomeningitisvirusinfectionofnewbornmiceantithymocyteserumeffectsonglomerulonephrotisandwastingdisease

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