BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT

Rat bone marrow is deficient in immunologically competent cells when compared with the peripheral pool of circulating small lymphocytes. However, circulating lymphocytes capable of initiating a lethal graft vs. host reaction can develop from myeloid precursors. In adult rats inoculated at birth with...

Descripción completa

Detalles Bibliográficos
Autor principal: McGregor, Douglas D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138482/
https://www.ncbi.nlm.nih.gov/pubmed/5655104
_version_ 1782143573552005120
author McGregor, Douglas D.
author_facet McGregor, Douglas D.
author_sort McGregor, Douglas D.
collection PubMed
description Rat bone marrow is deficient in immunologically competent cells when compared with the peripheral pool of circulating small lymphocytes. However, circulating lymphocytes capable of initiating a lethal graft vs. host reaction can develop from myeloid precursors. In adult rats inoculated at birth with parental strain bone marrow cells, the thoracic duct lymph contains cells having the immunological capability of the marrow donor. The evidence suggests that immunologically competent lymphocytes derive from cells normally resident in bone marrow and probably not from precursors in the peripheral lymphocyte pool.
format Text
id pubmed-2138482
institution National Center for Biotechnology Information
language English
publishDate 1968
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21384822008-04-17 BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT McGregor, Douglas D. J Exp Med Article Rat bone marrow is deficient in immunologically competent cells when compared with the peripheral pool of circulating small lymphocytes. However, circulating lymphocytes capable of initiating a lethal graft vs. host reaction can develop from myeloid precursors. In adult rats inoculated at birth with parental strain bone marrow cells, the thoracic duct lymph contains cells having the immunological capability of the marrow donor. The evidence suggests that immunologically competent lymphocytes derive from cells normally resident in bone marrow and probably not from precursors in the peripheral lymphocyte pool. The Rockefeller University Press 1968-05-01 /pmc/articles/PMC2138482/ /pubmed/5655104 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McGregor, Douglas D.
BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT
title BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT
title_full BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT
title_fullStr BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT
title_full_unstemmed BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT
title_short BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT
title_sort bone marrow origin of immunologically competent lymphocytes in the rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138482/
https://www.ncbi.nlm.nih.gov/pubmed/5655104
work_keys_str_mv AT mcgregordouglasd bonemarroworiginofimmunologicallycompetentlymphocytesintherat

Ejemplares similares