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INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM

1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally...

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Detalles Bibliográficos
Autores principales: Foster, Roger, Metcalf, Donald, Kirchmyer, Rosemary
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138494/
https://www.ncbi.nlm.nih.gov/pubmed/5655100
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author Foster, Roger
Metcalf, Donald
Kirchmyer, Rosemary
author_facet Foster, Roger
Metcalf, Donald
Kirchmyer, Rosemary
author_sort Foster, Roger
collection PubMed
description 1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells. 2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile. 3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice. 4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent.
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spelling pubmed-21384942008-04-17 INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM Foster, Roger Metcalf, Donald Kirchmyer, Rosemary J Exp Med Article 1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells. 2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile. 3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice. 4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent. The Rockefeller University Press 1968-05-01 /pmc/articles/PMC2138494/ /pubmed/5655100 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Foster, Roger
Metcalf, Donald
Kirchmyer, Rosemary
INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
title INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
title_full INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
title_fullStr INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
title_full_unstemmed INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
title_short INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
title_sort induction of bone marrow colony-stimulating activity by a filterable agent in leukemic and normal mouse serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138494/
https://www.ncbi.nlm.nih.gov/pubmed/5655100
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