THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS

Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody...

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Detalles Bibliográficos
Autor principal: Agnew, Hewes D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138510/
https://www.ncbi.nlm.nih.gov/pubmed/4873839
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author Agnew, Hewes D.
author_facet Agnew, Hewes D.
author_sort Agnew, Hewes D.
collection PubMed
description Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody could be detected on the surfaces of a high percentage of the lymph cells. Furthermore, the thoracic duct lymphocytes were unable to initiate graft vs. host reactions during the period of depletion, even when injected in extremely large doses. Approximately 2 wk after treatment, the numbers and immune competence of the small lymphocytes returned to normal.
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spelling pubmed-21385102008-04-17 THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS Agnew, Hewes D. J Exp Med Article Treatment of Lewis strain rats with a single subcutaneous dose of rabbit anti-rat thymocyte serum (RARTS) resulted in a marked depletion of small lymphocytes in the blood and thoracic duct lymph for approximately 10 days. While the thoracic duct lymphocytes were declining in numbers, rabbit antibody could be detected on the surfaces of a high percentage of the lymph cells. Furthermore, the thoracic duct lymphocytes were unable to initiate graft vs. host reactions during the period of depletion, even when injected in extremely large doses. Approximately 2 wk after treatment, the numbers and immune competence of the small lymphocytes returned to normal. The Rockefeller University Press 1968-07-01 /pmc/articles/PMC2138510/ /pubmed/4873839 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Agnew, Hewes D.
THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS
title THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS
title_full THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS
title_fullStr THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS
title_full_unstemmed THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS
title_short THE EFFECT OF HETEROLOGOUS ANTI-LYMPHOCYTIC SERUM ON THE SMALL LYMPHOCYTE POPULATION OF RATS
title_sort effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138510/
https://www.ncbi.nlm.nih.gov/pubmed/4873839
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