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PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER
When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibod...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1968
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138518/ https://www.ncbi.nlm.nih.gov/pubmed/4873023 |
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author | Root, Richard K. Wolff, Sheldon M. |
author_facet | Root, Richard K. Wolff, Sheldon M. |
author_sort | Root, Richard K. |
collection | PubMed |
description | When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state of febrile tolerance when repeatedly administered. The second pyrogen, demonstrable during fever in donor rabbits, appears to be similar to endogenous pyrogen described in other experimental fevers. It is postulated that the formation of antigen-antibody complexes constitutes an important initial phase of the febrile reaction in this type of immune fever. |
format | Text |
id | pubmed-2138518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1968 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21385182008-04-17 PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER Root, Richard K. Wolff, Sheldon M. J Exp Med Article When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state of febrile tolerance when repeatedly administered. The second pyrogen, demonstrable during fever in donor rabbits, appears to be similar to endogenous pyrogen described in other experimental fevers. It is postulated that the formation of antigen-antibody complexes constitutes an important initial phase of the febrile reaction in this type of immune fever. The Rockefeller University Press 1968-08-01 /pmc/articles/PMC2138518/ /pubmed/4873023 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Root, Richard K. Wolff, Sheldon M. PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER |
title | PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER |
title_full | PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER |
title_fullStr | PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER |
title_full_unstemmed | PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER |
title_short | PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER |
title_sort | pathogenetic mechanisms in experimental immune fever |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138518/ https://www.ncbi.nlm.nih.gov/pubmed/4873023 |
work_keys_str_mv | AT rootrichardk pathogeneticmechanismsinexperimentalimmunefever AT wolffsheldonm pathogeneticmechanismsinexperimentalimmunefever |