CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE

Pairs of rats were immunized with keyhole limpet hemocyanin (KLH) and simultaneously labeled with thymidine-methyl-(3)H or 5-iodo-2'-deoxyuridine-(125)I. From 10–50 days later, their lymphoid organs were examined 3 days after anamnestic stimulation with KLH or after primary injection of BGG. Li...

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Detalles Bibliográficos
Autores principales: Bosman, Cesare, Feldman, Joseph D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138521/
https://www.ncbi.nlm.nih.gov/pubmed/5659523
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author Bosman, Cesare
Feldman, Joseph D.
author_facet Bosman, Cesare
Feldman, Joseph D.
author_sort Bosman, Cesare
collection PubMed
description Pairs of rats were immunized with keyhole limpet hemocyanin (KLH) and simultaneously labeled with thymidine-methyl-(3)H or 5-iodo-2'-deoxyuridine-(125)I. From 10–50 days later, their lymphoid organs were examined 3 days after anamnestic stimulation with KLH or after primary injection of BGG. Light and electron microscopic study of the labeled cells revealed that immunologic memory resided in the mature resting monoribosomal lymphocyte which, upon stimulation, transformed to an immature polyribosomal lymphocyte and mitotically active blast cell. These latter elements differentiated into plasma cells directly or after mitosis.
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spelling pubmed-21385212008-04-17 CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE Bosman, Cesare Feldman, Joseph D. J Exp Med Article Pairs of rats were immunized with keyhole limpet hemocyanin (KLH) and simultaneously labeled with thymidine-methyl-(3)H or 5-iodo-2'-deoxyuridine-(125)I. From 10–50 days later, their lymphoid organs were examined 3 days after anamnestic stimulation with KLH or after primary injection of BGG. Light and electron microscopic study of the labeled cells revealed that immunologic memory resided in the mature resting monoribosomal lymphocyte which, upon stimulation, transformed to an immature polyribosomal lymphocyte and mitotically active blast cell. These latter elements differentiated into plasma cells directly or after mitosis. The Rockefeller University Press 1968-08-01 /pmc/articles/PMC2138521/ /pubmed/5659523 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bosman, Cesare
Feldman, Joseph D.
CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE
title CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE
title_full CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE
title_fullStr CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE
title_full_unstemmed CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE
title_short CYTOLOGY OF IMMUNOLOGIC MEMORY : A MORPHOLOGIC STUDY OF LYMPHOID CELLS DURING THE ANAMNESTIC RESPONSE
title_sort cytology of immunologic memory : a morphologic study of lymphoid cells during the anamnestic response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138521/
https://www.ncbi.nlm.nih.gov/pubmed/5659523
work_keys_str_mv AT bosmancesare cytologyofimmunologicmemoryamorphologicstudyoflymphoidcellsduringtheanamnesticresponse
AT feldmanjosephd cytologyofimmunologicmemoryamorphologicstudyoflymphoidcellsduringtheanamnesticresponse

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