CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of cho...

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Detalles Bibliográficos
Autores principales: Shulman, Herbert J., Meyer, Karl
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138571/
https://www.ncbi.nlm.nih.gov/pubmed/5688079
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author Shulman, Herbert J.
Meyer, Karl
author_facet Shulman, Herbert J.
Meyer, Karl
author_sort Shulman, Herbert J.
collection PubMed
description Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate. These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.
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spelling pubmed-21385712008-04-17 CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES Shulman, Herbert J. Meyer, Karl J Exp Med Article Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate. These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented. The Rockefeller University Press 1968-11-30 /pmc/articles/PMC2138571/ /pubmed/5688079 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Shulman, Herbert J.
Meyer, Karl
CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES
title CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES
title_full CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES
title_fullStr CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES
title_full_unstemmed CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES
title_short CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES
title_sort cellular differentiation and the aging process in cartilaginous tissues : mucopolysaccharide synthesis in cell cultures of chondrocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138571/
https://www.ncbi.nlm.nih.gov/pubmed/5688079
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