RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS

Mice injected intraperitoneally with isolated cell wall fragments of Group A streptococci develop a carditis similar to that previously observed in mice injected with crude extracts of this organism. Neither the soluble cytoplasmic components of Group A streptococcal cells nor the nonfragmented cell...

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Detalles Bibliográficos
Autores principales: Ohanian, S. H., Schwab, J. H., Cromartie, W. J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138592/
https://www.ncbi.nlm.nih.gov/pubmed/5782771
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author Ohanian, S. H.
Schwab, J. H.
Cromartie, W. J.
author_facet Ohanian, S. H.
Schwab, J. H.
Cromartie, W. J.
author_sort Ohanian, S. H.
collection PubMed
description Mice injected intraperitoneally with isolated cell wall fragments of Group A streptococci develop a carditis similar to that previously observed in mice injected with crude extracts of this organism. Neither the soluble cytoplasmic components of Group A streptococcal cells nor the nonfragmented cell walls produced carditis in this experimental model. Fluorescein and (125)I-labeled antibodies specific for Group A streptococcal cell wall antigens were used to demonstrate that, for 5 wk after injection, cell wall material is localized around the sites of active lesions in the heart. In addition, the cell wall antigen accumulates in the liver, spleen, mediastinal lymph nodes, and the adjacent loose connective tissue, where it persists for at least 10 wk.
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spelling pubmed-21385922008-04-17 RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS Ohanian, S. H. Schwab, J. H. Cromartie, W. J. J Exp Med Article Mice injected intraperitoneally with isolated cell wall fragments of Group A streptococci develop a carditis similar to that previously observed in mice injected with crude extracts of this organism. Neither the soluble cytoplasmic components of Group A streptococcal cells nor the nonfragmented cell walls produced carditis in this experimental model. Fluorescein and (125)I-labeled antibodies specific for Group A streptococcal cell wall antigens were used to demonstrate that, for 5 wk after injection, cell wall material is localized around the sites of active lesions in the heart. In addition, the cell wall antigen accumulates in the liver, spleen, mediastinal lymph nodes, and the adjacent loose connective tissue, where it persists for at least 10 wk. The Rockefeller University Press 1969-01-01 /pmc/articles/PMC2138592/ /pubmed/5782771 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ohanian, S. H.
Schwab, J. H.
Cromartie, W. J.
RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS
title RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS
title_full RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS
title_fullStr RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS
title_full_unstemmed RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS
title_short RELATION OF RHEUMATIC-LIKE CARDIAC LESIONS OF THE MOUSE TO LOCALIZATION OF GROUP A STREPTOCOCCAL CELL WALLS
title_sort relation of rheumatic-like cardiac lesions of the mouse to localization of group a streptococcal cell walls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138592/
https://www.ncbi.nlm.nih.gov/pubmed/5782771
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