THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION

Graft-vs.-host (GVH) reactions were performed in chicken embryos by intravenous injection of adult chicken blood dilutions, and the result was scored by weighing the spleens as well as by karyological identification of host and donor metaphases. From the frequency of detectable signs of GVH reaction...

Descripción completa

Detalles Bibliográficos
Autores principales: Nisbet, Norman W., Simonsen, Morten, Zaleski, Marek
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138611/
https://www.ncbi.nlm.nih.gov/pubmed/5766941
_version_ 1782143603719536640
author Nisbet, Norman W.
Simonsen, Morten
Zaleski, Marek
author_facet Nisbet, Norman W.
Simonsen, Morten
Zaleski, Marek
author_sort Nisbet, Norman W.
collection PubMed
description Graft-vs.-host (GVH) reactions were performed in chicken embryos by intravenous injection of adult chicken blood dilutions, and the result was scored by weighing the spleens as well as by karyological identification of host and donor metaphases. From the frequency of detectable signs of GVH reaction when low doses of donor cells were injected into hosts containing one foreign allele of the B locus it is concluded that 1–2% must be a minimum estimate for the frequency of antigen-sensitive cells of a given specificity in this system. It is not found possible to reconcile the findings with the strictest form of clonal selection which postulates a single receptor specificity per clone of antigen-sensitive cells.
format Text
id pubmed-2138611
institution National Center for Biotechnology Information
language English
publishDate 1969
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21386112008-04-17 THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION Nisbet, Norman W. Simonsen, Morten Zaleski, Marek J Exp Med Article Graft-vs.-host (GVH) reactions were performed in chicken embryos by intravenous injection of adult chicken blood dilutions, and the result was scored by weighing the spleens as well as by karyological identification of host and donor metaphases. From the frequency of detectable signs of GVH reaction when low doses of donor cells were injected into hosts containing one foreign allele of the B locus it is concluded that 1–2% must be a minimum estimate for the frequency of antigen-sensitive cells of a given specificity in this system. It is not found possible to reconcile the findings with the strictest form of clonal selection which postulates a single receptor specificity per clone of antigen-sensitive cells. The Rockefeller University Press 1969-02-28 /pmc/articles/PMC2138611/ /pubmed/5766941 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Nisbet, Norman W.
Simonsen, Morten
Zaleski, Marek
THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION
title THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION
title_full THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION
title_fullStr THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION
title_full_unstemmed THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION
title_short THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION : A COMMENTARY ON CLONAL SELECTION
title_sort frequency of antigen-sensitive cells in tissue transplantation : a commentary on clonal selection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138611/
https://www.ncbi.nlm.nih.gov/pubmed/5766941
work_keys_str_mv AT nisbetnormanw thefrequencyofantigensensitivecellsintissuetransplantationacommentaryonclonalselection
AT simonsenmorten thefrequencyofantigensensitivecellsintissuetransplantationacommentaryonclonalselection
AT zaleskimarek thefrequencyofantigensensitivecellsintissuetransplantationacommentaryonclonalselection
AT nisbetnormanw frequencyofantigensensitivecellsintissuetransplantationacommentaryonclonalselection
AT simonsenmorten frequencyofantigensensitivecellsintissuetransplantationacommentaryonclonalselection
AT zaleskimarek frequencyofantigensensitivecellsintissuetransplantationacommentaryonclonalselection

Ejemplares similares