THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION

Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction coul...

Descripción completa

Detalles Bibliográficos
Autores principales: Margaretten, William, McKay, Donald G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138615/
https://www.ncbi.nlm.nih.gov/pubmed/4886043
_version_ 1782143604650672128
author Margaretten, William
McKay, Donald G.
author_facet Margaretten, William
McKay, Donald G.
author_sort Margaretten, William
collection PubMed
description Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.
format Text
id pubmed-2138615
institution National Center for Biotechnology Information
language English
publishDate 1969
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21386152008-04-17 THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION Margaretten, William McKay, Donald G. J Exp Med Article Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions. The Rockefeller University Press 1969-02-28 /pmc/articles/PMC2138615/ /pubmed/4886043 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Margaretten, William
McKay, Donald G.
THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION
title THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION
title_full THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION
title_fullStr THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION
title_full_unstemmed THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION
title_short THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION
title_sort role of the platelet in the generalized shwartzman reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138615/
https://www.ncbi.nlm.nih.gov/pubmed/4886043
work_keys_str_mv AT margarettenwilliam theroleoftheplateletinthegeneralizedshwartzmanreaction
AT mckaydonaldg theroleoftheplateletinthegeneralizedshwartzmanreaction
AT margarettenwilliam roleoftheplateletinthegeneralizedshwartzmanreaction
AT mckaydonaldg roleoftheplateletinthegeneralizedshwartzmanreaction

Ejemplares similares