FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4

The fluid phase inactivation of C2(hu) by C1(hu) is markedly enhanced by the presence of C4(hu). The enhancement is afforded by C1 inactivated C4(hu), namely C4i(hu), and requires the simultaneous presence of enzymatically active C1. Heterologous C4 of guinea pig origin protects C2(hu) from the inac...

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Detalles Bibliográficos
Autores principales: Gigli, Irma, Austen, K. Frank
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138629/
https://www.ncbi.nlm.nih.gov/pubmed/5766946
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author Gigli, Irma
Austen, K. Frank
author_facet Gigli, Irma
Austen, K. Frank
author_sort Gigli, Irma
collection PubMed
description The fluid phase inactivation of C2(hu) by C1(hu) is markedly enhanced by the presence of C4(hu). The enhancement is afforded by C1 inactivated C4(hu), namely C4i(hu), and requires the simultaneous presence of enzymatically active C1. Heterologous C4 of guinea pig origin protects C2(hu) from the inactivation by C1(hu). Thus, in both the fluid phase and on the cellular intermediate, C4(hu) is essential to the specific action of C1(hu) on C2(hu). It is possible that C4i alters C2 so as to present a more suitable substrate to the C1 enzyme or that C4i acts on the C1 to uncover a specificity for native C2.
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spelling pubmed-21386292008-04-17 FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4 Gigli, Irma Austen, K. Frank J Exp Med Article The fluid phase inactivation of C2(hu) by C1(hu) is markedly enhanced by the presence of C4(hu). The enhancement is afforded by C1 inactivated C4(hu), namely C4i(hu), and requires the simultaneous presence of enzymatically active C1. Heterologous C4 of guinea pig origin protects C2(hu) from the inactivation by C1(hu). Thus, in both the fluid phase and on the cellular intermediate, C4(hu) is essential to the specific action of C1(hu) on C2(hu). It is possible that C4i alters C2 so as to present a more suitable substrate to the C1 enzyme or that C4i acts on the C1 to uncover a specificity for native C2. The Rockefeller University Press 1969-03-31 /pmc/articles/PMC2138629/ /pubmed/5766946 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gigli, Irma
Austen, K. Frank
FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4
title FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4
title_full FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4
title_fullStr FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4
title_full_unstemmed FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4
title_short FLUID PHASE DESTRUCTION OF C2(hu) BY C1(hu) : I. ITS ENHANCEMENT AND INHIBITION BY HOMOLOGOUS AND HETEROLOGOUS C4
title_sort fluid phase destruction of c2(hu) by c1(hu) : i. its enhancement and inhibition by homologous and heterologous c4
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138629/
https://www.ncbi.nlm.nih.gov/pubmed/5766946
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AT austenkfrank fluidphasedestructionofc2hubyc1huiitsenhancementandinhibitionbyhomologousandheterologousc4

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