THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY

Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding...

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Detalles Bibliográficos
Autores principales: Byfield, Patricia, Sercarz, Eli
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138634/
https://www.ncbi.nlm.nih.gov/pubmed/5305241
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author Byfield, Patricia
Sercarz, Eli
author_facet Byfield, Patricia
Sercarz, Eli
author_sort Byfield, Patricia
collection PubMed
description Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding to a second injection of antigen after short priming intervals begin to proliferate within hours. This implies a qualitative difference between the antigen-sensitive cells in primed and normal animals. After 1 day, further proliferative expansion of memory can occur, which is probably antigen dependent. The response to several dose regimens indicates that repeated antigenic contact is needed to maintain the IgM response.
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spelling pubmed-21386342008-04-17 THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY Byfield, Patricia Sercarz, Eli J Exp Med Article Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding to a second injection of antigen after short priming intervals begin to proliferate within hours. This implies a qualitative difference between the antigen-sensitive cells in primed and normal animals. After 1 day, further proliferative expansion of memory can occur, which is probably antigen dependent. The response to several dose regimens indicates that repeated antigenic contact is needed to maintain the IgM response. The Rockefeller University Press 1969-05-01 /pmc/articles/PMC2138634/ /pubmed/5305241 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Byfield, Patricia
Sercarz, Eli
THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY
title THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY
title_full THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY
title_fullStr THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY
title_full_unstemmed THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY
title_short THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION : VII. CELL DIVISION AND THE ESTABLISHMENT OF SHORT-TERM IGM MEMORY
title_sort x-y-z scheme of immunocyte maturation : vii. cell division and the establishment of short-term igm memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138634/
https://www.ncbi.nlm.nih.gov/pubmed/5305241
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