THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM

The fate of small doses of isotopically labeled isologous hemoglobin was studied in the rat. When haptoglobin depleted animals were given 2.0 mg of (59)Fe hemoglobin intravenously, nearly half was trapped by the kidneys. Kidney (59)Fe activity disappeared slowly over several weeks. Whatever iron was...

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Detalles Bibliográficos
Autores principales: Bunn, H. Franklin, Jandl, James H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138641/
https://www.ncbi.nlm.nih.gov/pubmed/5778790
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author Bunn, H. Franklin
Jandl, James H.
author_facet Bunn, H. Franklin
Jandl, James H.
author_sort Bunn, H. Franklin
collection PubMed
description The fate of small doses of isotopically labeled isologous hemoglobin was studied in the rat. When haptoglobin depleted animals were given 2.0 mg of (59)Fe hemoglobin intravenously, nearly half was trapped by the kidneys. Kidney (59)Fe activity disappeared slowly over several weeks. Whatever iron was lost from the kidneys was largely reutilized. In contrast, the porphyrin of hemoglobin absorbed by the kidneys appeared to be rapidly catabolized, since 5 hr after the injection of (14)C or (59)Fe heme-labeled hemoglobin only a small fraction was recovered as hematin. Likewise, after injection of globin-labeled hemoglobin, rapid disappearance of kidney protein activity indicated that the absorbed globin was readily catabolized in situ.
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spelling pubmed-21386412008-04-17 THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM Bunn, H. Franklin Jandl, James H. J Exp Med Article The fate of small doses of isotopically labeled isologous hemoglobin was studied in the rat. When haptoglobin depleted animals were given 2.0 mg of (59)Fe hemoglobin intravenously, nearly half was trapped by the kidneys. Kidney (59)Fe activity disappeared slowly over several weeks. Whatever iron was lost from the kidneys was largely reutilized. In contrast, the porphyrin of hemoglobin absorbed by the kidneys appeared to be rapidly catabolized, since 5 hr after the injection of (14)C or (59)Fe heme-labeled hemoglobin only a small fraction was recovered as hematin. Likewise, after injection of globin-labeled hemoglobin, rapid disappearance of kidney protein activity indicated that the absorbed globin was readily catabolized in situ. The Rockefeller University Press 1969-05-01 /pmc/articles/PMC2138641/ /pubmed/5778790 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bunn, H. Franklin
Jandl, James H.
THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM
title THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM
title_full THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM
title_fullStr THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM
title_full_unstemmed THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM
title_short THE RENAL HANDLING OF HEMOGLOBIN : II. CATABOLISM
title_sort renal handling of hemoglobin : ii. catabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138641/
https://www.ncbi.nlm.nih.gov/pubmed/5778790
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AT jandljamesh renalhandlingofhemoglobiniicatabolism

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