HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS

High molecular weight group A and group C meningococcal polysaccharides had no significant toxicity for mice or guinea pigs. Furthermore, these polysaccharide preparations contained negligible amounts of biologically active endotoxin. The high molecular weight group A and group C meningococcal polys...

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Detalles Bibliográficos
Autores principales: Gotschlich, Emil C., Goldschneider, Irving, Artenstein, Malcolm S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138657/
https://www.ncbi.nlm.nih.gov/pubmed/4977283
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author Gotschlich, Emil C.
Goldschneider, Irving
Artenstein, Malcolm S.
author_facet Gotschlich, Emil C.
Goldschneider, Irving
Artenstein, Malcolm S.
author_sort Gotschlich, Emil C.
collection PubMed
description High molecular weight group A and group C meningococcal polysaccharides had no significant toxicity for mice or guinea pigs. Furthermore, these polysaccharide preparations contained negligible amounts of biologically active endotoxin. The high molecular weight group A and group C meningococcal polysaccharides were excellent immunogens in six human volunteers. Antibodies belonging to the immunoglobulin classes IgG, IgM, and IgA were produced. These antibodies were highly meningococcocidal in the presence of complement.
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spelling pubmed-21386572008-04-17 HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS Gotschlich, Emil C. Goldschneider, Irving Artenstein, Malcolm S. J Exp Med Article High molecular weight group A and group C meningococcal polysaccharides had no significant toxicity for mice or guinea pigs. Furthermore, these polysaccharide preparations contained negligible amounts of biologically active endotoxin. The high molecular weight group A and group C meningococcal polysaccharides were excellent immunogens in six human volunteers. Antibodies belonging to the immunoglobulin classes IgG, IgM, and IgA were produced. These antibodies were highly meningococcocidal in the presence of complement. The Rockefeller University Press 1969-06-01 /pmc/articles/PMC2138657/ /pubmed/4977283 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gotschlich, Emil C.
Goldschneider, Irving
Artenstein, Malcolm S.
HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS
title HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS
title_full HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS
title_fullStr HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS
title_full_unstemmed HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS
title_short HUMAN IMMUNITY TO THE MENINGOCOCCUS : IV. IMMUNOGENICITY OF GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES IN HUMAN VOLUNTEERS
title_sort human immunity to the meningococcus : iv. immunogenicity of group a and group c meningococcal polysaccharides in human volunteers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138657/
https://www.ncbi.nlm.nih.gov/pubmed/4977283
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AT artensteinmalcolms humanimmunitytothemeningococcusivimmunogenicityofgroupaandgroupcmeningococcalpolysaccharidesinhumanvolunteers

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