HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE

Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individua...

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Detalles Bibliográficos
Autores principales: Gotschlich, Emil C., Goldschneider, Irving, Artenstein, Malcolm S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138662/
https://www.ncbi.nlm.nih.gov/pubmed/4977284
Descripción
Sumario:Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individuals with the exception of two recruits injected with A polysaccharide. During the 6 wk period of observation, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 per cent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci; 4.6, 24, and 31 per cent respectively.

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