HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE

Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individua...

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Detalles Bibliográficos
Autores principales: Gotschlich, Emil C., Goldschneider, Irving, Artenstein, Malcolm S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138662/
https://www.ncbi.nlm.nih.gov/pubmed/4977284
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author Gotschlich, Emil C.
Goldschneider, Irving
Artenstein, Malcolm S.
author_facet Gotschlich, Emil C.
Goldschneider, Irving
Artenstein, Malcolm S.
author_sort Gotschlich, Emil C.
collection PubMed
description Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individuals with the exception of two recruits injected with A polysaccharide. During the 6 wk period of observation, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 per cent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci; 4.6, 24, and 31 per cent respectively.
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spelling pubmed-21386622008-04-17 HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE Gotschlich, Emil C. Goldschneider, Irving Artenstein, Malcolm S. J Exp Med Article Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individuals with the exception of two recruits injected with A polysaccharide. During the 6 wk period of observation, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 per cent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci; 4.6, 24, and 31 per cent respectively. The Rockefeller University Press 1969-06-01 /pmc/articles/PMC2138662/ /pubmed/4977284 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gotschlich, Emil C.
Goldschneider, Irving
Artenstein, Malcolm S.
HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE
title HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE
title_full HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE
title_fullStr HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE
title_full_unstemmed HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE
title_short HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE
title_sort human immunity to the meningococcus : v. the effect of immunization with meningococcal group c polysaccharide on the carrier state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138662/
https://www.ncbi.nlm.nih.gov/pubmed/4977284
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