BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI

Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 µg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only pa...

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Detalles Bibliográficos
Autores principales: Rotta, Jiři, Bednář, Blahoslav
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138676/
https://www.ncbi.nlm.nih.gov/pubmed/4893096
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author Rotta, Jiři
Bednář, Blahoslav
author_facet Rotta, Jiři
Bednář, Blahoslav
author_sort Rotta, Jiři
collection PubMed
description Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 µg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction. Intravenous injection of 80 µg of solubilized mucopeptide leads to diffuse cellular infiltration as well as focal areas of myocardial necrosis, surrounded by inflammatory cells.
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spelling pubmed-21386762008-04-17 BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI Rotta, Jiři Bednář, Blahoslav J Exp Med Article Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 µg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction. Intravenous injection of 80 µg of solubilized mucopeptide leads to diffuse cellular infiltration as well as focal areas of myocardial necrosis, surrounded by inflammatory cells. The Rockefeller University Press 1969-07-01 /pmc/articles/PMC2138676/ /pubmed/4893096 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rotta, Jiři
Bednář, Blahoslav
BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
title BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
title_full BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
title_fullStr BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
title_full_unstemmed BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
title_short BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI
title_sort biological properties of cell wall mucopeptide of hemolytic streptococci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138676/
https://www.ncbi.nlm.nih.gov/pubmed/4893096
work_keys_str_mv AT rottajiri biologicalpropertiesofcellwallmucopeptideofhemolyticstreptococci
AT bednarblahoslav biologicalpropertiesofcellwallmucopeptideofhemolyticstreptococci

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