IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS

Unilateral thermal injury to guinea pig testes has elicited the formation of organ- and species-specific antibodies against a testicular antigen. The antibodies were of an IgG(1) nature, and reacted with autologous as well as homologous testicular extracts. A significant number of burned animals sho...

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Autores principales: Rapaport, Felix T., Sampath, Angus, Kano, Kyiochi, McCluskey, Robert T., Milgrom, Felix
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138690/
https://www.ncbi.nlm.nih.gov/pubmed/4982027
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author Rapaport, Felix T.
Sampath, Angus
Kano, Kyiochi
McCluskey, Robert T.
Milgrom, Felix
author_facet Rapaport, Felix T.
Sampath, Angus
Kano, Kyiochi
McCluskey, Robert T.
Milgrom, Felix
author_sort Rapaport, Felix T.
collection PubMed
description Unilateral thermal injury to guinea pig testes has elicited the formation of organ- and species-specific antibodies against a testicular antigen. The antibodies were of an IgG(1) nature, and reacted with autologous as well as homologous testicular extracts. A significant number of burned animals showed pathological changes in the contralateral testis, which were similar to those observed after the induction of experimental allergic orchitis by active immunization with testicular tissue. These results indicate that thermal injury may be associated with autoimmunization of the host by the injured organ.
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spelling pubmed-21386902008-04-17 IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS Rapaport, Felix T. Sampath, Angus Kano, Kyiochi McCluskey, Robert T. Milgrom, Felix J Exp Med Article Unilateral thermal injury to guinea pig testes has elicited the formation of organ- and species-specific antibodies against a testicular antigen. The antibodies were of an IgG(1) nature, and reacted with autologous as well as homologous testicular extracts. A significant number of burned animals showed pathological changes in the contralateral testis, which were similar to those observed after the induction of experimental allergic orchitis by active immunization with testicular tissue. These results indicate that thermal injury may be associated with autoimmunization of the host by the injured organ. The Rockefeller University Press 1969-11-30 /pmc/articles/PMC2138690/ /pubmed/4982027 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rapaport, Felix T.
Sampath, Angus
Kano, Kyiochi
McCluskey, Robert T.
Milgrom, Felix
IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS
title IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS
title_full IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS
title_fullStr IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS
title_full_unstemmed IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS
title_short IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS
title_sort immunological effects of thermal injury : i. inhibition of spermatogenesis in guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138690/
https://www.ncbi.nlm.nih.gov/pubmed/4982027
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