CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS

By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to el...

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Detalles Bibliográficos
Autores principales: Abdou, Nabih I., Rose, Bram, Richter, Maxwell
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138722/
https://www.ncbi.nlm.nih.gov/pubmed/5343438
Descripción
Sumario:By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.

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