CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS

By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to el...

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Detalles Bibliográficos
Autores principales: Abdou, Nabih I., Rose, Bram, Richter, Maxwell
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138722/
https://www.ncbi.nlm.nih.gov/pubmed/5343438
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author Abdou, Nabih I.
Rose, Bram
Richter, Maxwell
author_facet Abdou, Nabih I.
Rose, Bram
Richter, Maxwell
author_sort Abdou, Nabih I.
collection PubMed
description By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.
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spelling pubmed-21387222008-04-17 CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS Abdou, Nabih I. Rose, Bram Richter, Maxwell J Exp Med Article By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit. The Rockefeller University Press 1969-10-01 /pmc/articles/PMC2138722/ /pubmed/5343438 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Abdou, Nabih I.
Rose, Bram
Richter, Maxwell
CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS
title CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS
title_full CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS
title_fullStr CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS
title_full_unstemmed CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS
title_short CELLS INVOLVED IN THE IMMUNE RESPONSE : VIII. THE RELATIONSHIP BETWEEN THE LOSS AND REAPPEARANCE OF ANTIGEN-REACTIVE CELLS AND IMMUNE RESPONSIVENESS AFTER IRRADIATION OF NORMAL ADULT RABBITS
title_sort cells involved in the immune response : viii. the relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138722/
https://www.ncbi.nlm.nih.gov/pubmed/5343438
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AT richtermaxwell cellsinvolvedintheimmuneresponseviiitherelationshipbetweenthelossandreappearanceofantigenreactivecellsandimmuneresponsivenessafterirradiationofnormaladultrabbits

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