ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE

Immunological tolerance to H antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic dose of polymerized flagellin in the presence of low concentrations of specific antibody. Such antibody-mediated tolerance requires an optimal antigen...

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Detalles Bibliográficos
Autores principales: Diener, Erwin, Feldmann, Marc
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138743/
https://www.ncbi.nlm.nih.gov/pubmed/4927595
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author Diener, Erwin
Feldmann, Marc
author_facet Diener, Erwin
Feldmann, Marc
author_sort Diener, Erwin
collection PubMed
description Immunological tolerance to H antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic dose of polymerized flagellin in the presence of low concentrations of specific antibody. Such antibody-mediated tolerance requires an optimal antigen: antibody ratio for its induction. A shift in this ratio in favor of the antibody concentration results in failure of tolerance induction and leads to immune suppression commonly known as antibody-mediated feedback inhibition which is not analogous to immunological tolerance. Fragment A of flagellin fails to induce immunological tolerance in vitro. Tolerance to polymerized flagellin may however be induced in vitro, provided the spleen cells are exposed to fragment A in the presence of specific antibody for 6 hr. The results are discussed in the light of current theories of the mechanism of tolerance induction.
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spelling pubmed-21387432008-04-17 ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE Diener, Erwin Feldmann, Marc J Exp Med Article Immunological tolerance to H antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic dose of polymerized flagellin in the presence of low concentrations of specific antibody. Such antibody-mediated tolerance requires an optimal antigen: antibody ratio for its induction. A shift in this ratio in favor of the antibody concentration results in failure of tolerance induction and leads to immune suppression commonly known as antibody-mediated feedback inhibition which is not analogous to immunological tolerance. Fragment A of flagellin fails to induce immunological tolerance in vitro. Tolerance to polymerized flagellin may however be induced in vitro, provided the spleen cells are exposed to fragment A in the presence of specific antibody for 6 hr. The results are discussed in the light of current theories of the mechanism of tolerance induction. The Rockefeller University Press 1970-07-01 /pmc/articles/PMC2138743/ /pubmed/4927595 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Diener, Erwin
Feldmann, Marc
ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE
title ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE
title_full ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE
title_fullStr ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE
title_full_unstemmed ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE
title_short ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO : II. A NEW APPROACH TO THE PHENOMENON OF IMMUNOLOGICAL TOLERANCE
title_sort antibody-mediated suppression of the immune response in vitro : ii. a new approach to the phenomenon of immunological tolerance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138743/
https://www.ncbi.nlm.nih.gov/pubmed/4927595
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AT feldmannmarc antibodymediatedsuppressionoftheimmuneresponseinvitroiianewapproachtothephenomenonofimmunologicaltolerance

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