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STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES
Suppression of the pyrogen-producing capacity of exudate granulocytes results from incubation of the cells in plasma, serum, or Ringer's solution. When transferred in this state and incubated in isotonic NaCl, the cells release much less pyrogen than untreated exudate cells. The suppressive eff...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1970
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138746/ https://www.ncbi.nlm.nih.gov/pubmed/5508243 |
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author | Cheuk, S. Fai Hahn, Helmut H. Moore, Douglas M. Krause, Donald N. Tomasulo, Peter A. Wood, W. Barry |
author_facet | Cheuk, S. Fai Hahn, Helmut H. Moore, Douglas M. Krause, Donald N. Tomasulo, Peter A. Wood, W. Barry |
author_sort | Cheuk, S. Fai |
collection | PubMed |
description | Suppression of the pyrogen-producing capacity of exudate granulocytes results from incubation of the cells in plasma, serum, or Ringer's solution. When transferred in this state and incubated in isotonic NaCl, the cells release much less pyrogen than untreated exudate cells. The suppressive effect is reversible and appears to involve the cellular uptake of calcium ions. In contrast, regeneration of pyrogen-producing capacity in depleted exudate cells occurs only when the cells are incubated in serum. The process resembles activation and requires the cellular synthesis of protein. |
format | Text |
id | pubmed-2138746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1970 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21387462008-04-17 STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES Cheuk, S. Fai Hahn, Helmut H. Moore, Douglas M. Krause, Donald N. Tomasulo, Peter A. Wood, W. Barry J Exp Med Article Suppression of the pyrogen-producing capacity of exudate granulocytes results from incubation of the cells in plasma, serum, or Ringer's solution. When transferred in this state and incubated in isotonic NaCl, the cells release much less pyrogen than untreated exudate cells. The suppressive effect is reversible and appears to involve the cellular uptake of calcium ions. In contrast, regeneration of pyrogen-producing capacity in depleted exudate cells occurs only when the cells are incubated in serum. The process resembles activation and requires the cellular synthesis of protein. The Rockefeller University Press 1970-07-01 /pmc/articles/PMC2138746/ /pubmed/5508243 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Cheuk, S. Fai Hahn, Helmut H. Moore, Douglas M. Krause, Donald N. Tomasulo, Peter A. Wood, W. Barry STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES |
title | STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES |
title_full | STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES |
title_fullStr | STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES |
title_full_unstemmed | STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES |
title_short | STUDIES ON THE PATHOGENESIS OF FEVER : XX. SUPPRESSION AND REGENERATION OF PYROGEN-PRODUCING CAPACITY OF EXUDATE GRANULOCYTES |
title_sort | studies on the pathogenesis of fever : xx. suppression and regeneration of pyrogen-producing capacity of exudate granulocytes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138746/ https://www.ncbi.nlm.nih.gov/pubmed/5508243 |
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