STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION

Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involv...

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Detalles Bibliográficos
Autores principales: Moore, Douglas M., Cheuk, S. Fai, Morton, J. Dennis, Berlin, Richard D., Wood, W. Barry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138759/
https://www.ncbi.nlm.nih.gov/pubmed/4902892
Descripción
Sumario:Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involves the synthesis of cellular protein, presumably related to the pyrogen molecule. Evidence is presented that generation of pyrogen in sterile inflammatory lesions depends on both the activator and the anaerobic conditions in the exudate fluid.

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