STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION

Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involv...

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Detalles Bibliográficos
Autores principales: Moore, Douglas M., Cheuk, S. Fai, Morton, J. Dennis, Berlin, Richard D., Wood, W. Barry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138759/
https://www.ncbi.nlm.nih.gov/pubmed/4902892
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author Moore, Douglas M.
Cheuk, S. Fai
Morton, J. Dennis
Berlin, Richard D.
Wood, W. Barry
author_facet Moore, Douglas M.
Cheuk, S. Fai
Morton, J. Dennis
Berlin, Richard D.
Wood, W. Barry
author_sort Moore, Douglas M.
collection PubMed
description Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involves the synthesis of cellular protein, presumably related to the pyrogen molecule. Evidence is presented that generation of pyrogen in sterile inflammatory lesions depends on both the activator and the anaerobic conditions in the exudate fluid.
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spelling pubmed-21387592008-04-17 STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION Moore, Douglas M. Cheuk, S. Fai Morton, J. Dennis Berlin, Richard D. Wood, W. Barry J Exp Med Article Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involves the synthesis of cellular protein, presumably related to the pyrogen molecule. Evidence is presented that generation of pyrogen in sterile inflammatory lesions depends on both the activator and the anaerobic conditions in the exudate fluid. The Rockefeller University Press 1970-01-01 /pmc/articles/PMC2138759/ /pubmed/4902892 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Moore, Douglas M.
Cheuk, S. Fai
Morton, J. Dennis
Berlin, Richard D.
Wood, W. Barry
STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION
title STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION
title_full STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION
title_fullStr STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION
title_full_unstemmed STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION
title_short STUDIES ON THE PATHOGENESIS OF FEVER : XVIII. ACTIVATION OF LEUKOCYTES FOR PYROGEN PRODUCTION
title_sort studies on the pathogenesis of fever : xviii. activation of leukocytes for pyrogen production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138759/
https://www.ncbi.nlm.nih.gov/pubmed/4902892
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