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POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS

A highly purified pneumococcal polysaccharide (Type II SSS) is a very efficient inducer of delayed hypersensitivity in random-bred guinea pigs. The cellular reactivity induced by this polysaccharide administered subcutaneously in complete Freund's adjuvant is of "tuberculin type"; it...

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Detalles Bibliográficos
Autores principales: Gerety, Robert J., Ferraresi, Rodolfo W., Raffel, Sidney
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138760/
https://www.ncbi.nlm.nih.gov/pubmed/4391280
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author Gerety, Robert J.
Ferraresi, Rodolfo W.
Raffel, Sidney
author_facet Gerety, Robert J.
Ferraresi, Rodolfo W.
Raffel, Sidney
author_sort Gerety, Robert J.
collection PubMed
description A highly purified pneumococcal polysaccharide (Type II SSS) is a very efficient inducer of delayed hypersensitivity in random-bred guinea pigs. The cellular reactivity induced by this polysaccharide administered subcutaneously in complete Freund's adjuvant is of "tuberculin type"; it increases in intensity with time after the sensitizing injection, as judged by skin tests, the macrophage inhibition reaction and transfer of reactivity by peritoneal exudate cells. By contrast, the cellular reactivity induced by this immunogen in the absence of mycobacterial adjuvant has the characteristics of "Jones-Mote" reactivity. It is best seen at about 1 wk after sensitization; the reactions are characteristically little indurated and show histologic differences from tuberculin type responses; and the reactive state begins to disappear by 2–3 wk, with the accession of Arthus reactivity. This type of delayed reactivity may be related to an early phase of antibody synthesis.
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spelling pubmed-21387602008-04-17 POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS Gerety, Robert J. Ferraresi, Rodolfo W. Raffel, Sidney J Exp Med Article A highly purified pneumococcal polysaccharide (Type II SSS) is a very efficient inducer of delayed hypersensitivity in random-bred guinea pigs. The cellular reactivity induced by this polysaccharide administered subcutaneously in complete Freund's adjuvant is of "tuberculin type"; it increases in intensity with time after the sensitizing injection, as judged by skin tests, the macrophage inhibition reaction and transfer of reactivity by peritoneal exudate cells. By contrast, the cellular reactivity induced by this immunogen in the absence of mycobacterial adjuvant has the characteristics of "Jones-Mote" reactivity. It is best seen at about 1 wk after sensitization; the reactions are characteristically little indurated and show histologic differences from tuberculin type responses; and the reactive state begins to disappear by 2–3 wk, with the accession of Arthus reactivity. This type of delayed reactivity may be related to an early phase of antibody synthesis. The Rockefeller University Press 1970-01-01 /pmc/articles/PMC2138760/ /pubmed/4391280 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gerety, Robert J.
Ferraresi, Rodolfo W.
Raffel, Sidney
POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS
title POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS
title_full POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS
title_fullStr POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS
title_full_unstemmed POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS
title_short POLYSACCHARIDE IN DELAYED HYPERSENSITIVITY : I. PNEUMOCOCCAL POLYSACCHARIDE AS INDUCER AND ELICITOR OF DELAYED REACTIVITY IN GUINEA PIGS
title_sort polysaccharide in delayed hypersensitivity : i. pneumococcal polysaccharide as inducer and elicitor of delayed reactivity in guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138760/
https://www.ncbi.nlm.nih.gov/pubmed/4391280
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