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GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY

Virus transformants (like cancer cells, cells transformed by X-ray or carcinogens, or those which have transformed spontaneously) exhibit a number of phenotypic changes which are usually associated, and which may be lost concurrently. That association is, however, not invariable. More particularly,...

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Detalles Bibliográficos
Autores principales: Eagle, H., Foley, G. E., Koprowski, H., Lazarus, H., Levine, E. M., Adams, R. A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138771/
https://www.ncbi.nlm.nih.gov/pubmed/4317881
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author Eagle, H.
Foley, G. E.
Koprowski, H.
Lazarus, H.
Levine, E. M.
Adams, R. A.
author_facet Eagle, H.
Foley, G. E.
Koprowski, H.
Lazarus, H.
Levine, E. M.
Adams, R. A.
author_sort Eagle, H.
collection PubMed
description Virus transformants (like cancer cells, cells transformed by X-ray or carcinogens, or those which have transformed spontaneously) exhibit a number of phenotypic changes which are usually associated, and which may be lost concurrently. That association is, however, not invariable. More particularly, the altered characteristics here studied (escape from contact inhibition of growth and susceptibility to inhibition by other cells, decreased serum requirement, and ability to grow in soft agar) do not, in and of themselves, endow the cell with the capacity to produce a tumor, at least as judged by the methods of assay here used. Although the question as to whether the tumorigenicity of virus transformants is causally linked to any of these associated changes cannot be answered definitively, the evidence suggests a close linkage, rather than identity, between the determinants of oncogenicity and the other properties here studied.
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spelling pubmed-21387712008-04-17 GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY Eagle, H. Foley, G. E. Koprowski, H. Lazarus, H. Levine, E. M. Adams, R. A. J Exp Med Article Virus transformants (like cancer cells, cells transformed by X-ray or carcinogens, or those which have transformed spontaneously) exhibit a number of phenotypic changes which are usually associated, and which may be lost concurrently. That association is, however, not invariable. More particularly, the altered characteristics here studied (escape from contact inhibition of growth and susceptibility to inhibition by other cells, decreased serum requirement, and ability to grow in soft agar) do not, in and of themselves, endow the cell with the capacity to produce a tumor, at least as judged by the methods of assay here used. Although the question as to whether the tumorigenicity of virus transformants is causally linked to any of these associated changes cannot be answered definitively, the evidence suggests a close linkage, rather than identity, between the determinants of oncogenicity and the other properties here studied. The Rockefeller University Press 1970-03-31 /pmc/articles/PMC2138771/ /pubmed/4317881 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Eagle, H.
Foley, G. E.
Koprowski, H.
Lazarus, H.
Levine, E. M.
Adams, R. A.
GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY
title GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY
title_full GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY
title_fullStr GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY
title_full_unstemmed GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY
title_short GROWTH CHARACTERISTICS OF VIRUS-TRANSFORMED CELLS : MAXIMUM POPULATION DENSITY, INHIBITION BY NORMAL CELLS, SERUM REQUIREMENT, GROWTH IN SOFT AGAR, AND XENOGENEIC TRANSPLANTABILITY
title_sort growth characteristics of virus-transformed cells : maximum population density, inhibition by normal cells, serum requirement, growth in soft agar, and xenogeneic transplantability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138771/
https://www.ncbi.nlm.nih.gov/pubmed/4317881
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