HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE

A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary functio...

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Detalles Bibliográficos
Autores principales: Huggins, Charles, Grand, Lorraine, Oka, Hisao
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138796/
https://www.ncbi.nlm.nih.gov/pubmed/5419851
Descripción
Sumario:A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.

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