HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE

A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary functio...

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Detalles Bibliográficos
Autores principales: Huggins, Charles, Grand, Lorraine, Oka, Hisao
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138796/
https://www.ncbi.nlm.nih.gov/pubmed/5419851
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author Huggins, Charles
Grand, Lorraine
Oka, Hisao
author_facet Huggins, Charles
Grand, Lorraine
Oka, Hisao
author_sort Huggins, Charles
collection PubMed
description A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.
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spelling pubmed-21387962008-04-17 HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE Huggins, Charles Grand, Lorraine Oka, Hisao J Exp Med Article A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat. The Rockefeller University Press 1970-01-31 /pmc/articles/PMC2138796/ /pubmed/5419851 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Huggins, Charles
Grand, Lorraine
Oka, Hisao
HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
title HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
title_full HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
title_fullStr HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
title_full_unstemmed HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
title_short HUNDRED DAY LEUKEMIA: PREFERENTIAL INDUCTION IN RAT BY PULSE-DOSES OF 7,8,12-TRIMETHYLBENZ(A)ANTHRACENE
title_sort hundred day leukemia: preferential induction in rat by pulse-doses of 7,8,12-trimethylbenz(a)anthracene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138796/
https://www.ncbi.nlm.nih.gov/pubmed/5419851
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AT okahisao hundreddayleukemiapreferentialinductioninratbypulsedosesof7812trimethylbenzaanthracene

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