IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES

A partially purified blood group-like substance obtained from milk showed I activity with 2 of 21 anti-I sera. With these antisera, certain human ovarian cyst substances considered to be precursors of the A, B, H, Le(a), and Le(b) substances also showed I activity comparable to the milk material. St...

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Detalles Bibliográficos
Autores principales: Feizi, Ten, Kabat, Elvin A., Vicari, Giuseppe, Anderson, Byron, Marsh, W. Laurence
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138890/
https://www.ncbi.nlm.nih.gov/pubmed/5107432
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author Feizi, Ten
Kabat, Elvin A.
Vicari, Giuseppe
Anderson, Byron
Marsh, W. Laurence
author_facet Feizi, Ten
Kabat, Elvin A.
Vicari, Giuseppe
Anderson, Byron
Marsh, W. Laurence
author_sort Feizi, Ten
collection PubMed
description A partially purified blood group-like substance obtained from milk showed I activity with 2 of 21 anti-I sera. With these antisera, certain human ovarian cyst substances considered to be precursors of the A, B, H, Le(a), and Le(b) substances also showed I activity comparable to the milk material. Strong I activity could be produced by one-stage periodate oxidation and Smith degradation of human ovarian cyst A and B substances, or of hog mucin A + H substance, or by mild acid hydrolysis of human saliva or ovarian cyst blood group B substance. The two sera indicate that I specificity appears at intermediate stages in the biosynthesis of the A, B, H, Le(a), and Le(a) substances. Anti-I sera differ strikingly in their specificities, indicating substantial heterogeneity of the I determinants.
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spelling pubmed-21388902008-04-17 IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES Feizi, Ten Kabat, Elvin A. Vicari, Giuseppe Anderson, Byron Marsh, W. Laurence J Exp Med Article A partially purified blood group-like substance obtained from milk showed I activity with 2 of 21 anti-I sera. With these antisera, certain human ovarian cyst substances considered to be precursors of the A, B, H, Le(a), and Le(b) substances also showed I activity comparable to the milk material. Strong I activity could be produced by one-stage periodate oxidation and Smith degradation of human ovarian cyst A and B substances, or of hog mucin A + H substance, or by mild acid hydrolysis of human saliva or ovarian cyst blood group B substance. The two sera indicate that I specificity appears at intermediate stages in the biosynthesis of the A, B, H, Le(a), and Le(a) substances. Anti-I sera differ strikingly in their specificities, indicating substantial heterogeneity of the I determinants. The Rockefeller University Press 1971-01-01 /pmc/articles/PMC2138890/ /pubmed/5107432 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Feizi, Ten
Kabat, Elvin A.
Vicari, Giuseppe
Anderson, Byron
Marsh, W. Laurence
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
title IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
title_full IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
title_fullStr IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
title_full_unstemmed IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
title_short IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XLVII. THE I ANTIGEN COMPLEX — PRECURSORS IN THE A, B, H, LE(a), AND LE(b) BLOOD GROUP SYSTEM — HEMAGGLUTINATION-INHIBITION STUDIES
title_sort immunochemical studies on blood groups : xlvii. the i antigen complex — precursors in the a, b, h, le(a), and le(b) blood group system — hemagglutination-inhibition studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138890/
https://www.ncbi.nlm.nih.gov/pubmed/5107432
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