ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN

An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brai...

Descripción completa

Detalles Bibliográficos
Autores principales: Fischer-Ferraro, Catalina, Nahmod, Victor E., Goldstein, Daniel J., Finkielman, Samuel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138896/
https://www.ncbi.nlm.nih.gov/pubmed/4332372
_version_ 1782143669871050752
author Fischer-Ferraro, Catalina
Nahmod, Victor E.
Goldstein, Daniel J.
Finkielman, Samuel
author_facet Fischer-Ferraro, Catalina
Nahmod, Victor E.
Goldstein, Daniel J.
Finkielman, Samuel
author_sort Fischer-Ferraro, Catalina
collection PubMed
description An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brain extracts of dogs and rats. This activity was due to a substance identified by chemical and pharmacological tests as angiotensin. Countercurrent distribution of brain extracts of rats showed that 38% of the pressor activity corresponded to angiotensin II and the remainder to angiotensin I. A remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog.
format Text
id pubmed-2138896
institution National Center for Biotechnology Information
language English
publishDate 1971
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21388962008-04-17 ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN Fischer-Ferraro, Catalina Nahmod, Victor E. Goldstein, Daniel J. Finkielman, Samuel J Exp Med Article An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brain extracts of dogs and rats. This activity was due to a substance identified by chemical and pharmacological tests as angiotensin. Countercurrent distribution of brain extracts of rats showed that 38% of the pressor activity corresponded to angiotensin II and the remainder to angiotensin I. A remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog. The Rockefeller University Press 1971-01-31 /pmc/articles/PMC2138896/ /pubmed/4332372 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fischer-Ferraro, Catalina
Nahmod, Victor E.
Goldstein, Daniel J.
Finkielman, Samuel
ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
title ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
title_full ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
title_fullStr ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
title_full_unstemmed ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
title_short ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN
title_sort angiotensin and renin in rat and dog brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138896/
https://www.ncbi.nlm.nih.gov/pubmed/4332372
work_keys_str_mv AT fischerferrarocatalina angiotensinandrenininratanddogbrain
AT nahmodvictore angiotensinandrenininratanddogbrain
AT goldsteindanielj angiotensinandrenininratanddogbrain
AT finkielmansamuel angiotensinandrenininratanddogbrain

Ejemplares similares