MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE

Enhanced resistance against experimental tuberculosis was acquired by albino mice after peritoneal vaccination with living BCG. Prolongation of life was used as a measure of resistance against massive intravenous challenge infection. The average degree of prolongation of life was found to be directl...

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Detalles Bibliográficos
Autores principales: Costello, Richard, Izumi, Takateru
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138908/
https://www.ncbi.nlm.nih.gov/pubmed/5133864
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author Costello, Richard
Izumi, Takateru
author_facet Costello, Richard
Izumi, Takateru
author_sort Costello, Richard
collection PubMed
description Enhanced resistance against experimental tuberculosis was acquired by albino mice after peritoneal vaccination with living BCG. Prolongation of life was used as a measure of resistance against massive intravenous challenge infection. The average degree of prolongation of life was found to be directly related to the size of the vaccinating dose. The ultimate numbers of BCG bacilli recovered from the animal's organs were also directly related to the quantity of vaccine initially administered. It appears therefore that the relative degree of antitubercular resistance achieved by immunized mice is closely related to the vaccinal population present in the animal's organs.
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spelling pubmed-21389082008-04-17 MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE Costello, Richard Izumi, Takateru J Exp Med Article Enhanced resistance against experimental tuberculosis was acquired by albino mice after peritoneal vaccination with living BCG. Prolongation of life was used as a measure of resistance against massive intravenous challenge infection. The average degree of prolongation of life was found to be directly related to the size of the vaccinating dose. The ultimate numbers of BCG bacilli recovered from the animal's organs were also directly related to the quantity of vaccine initially administered. It appears therefore that the relative degree of antitubercular resistance achieved by immunized mice is closely related to the vaccinal population present in the animal's organs. The Rockefeller University Press 1971-01-31 /pmc/articles/PMC2138908/ /pubmed/5133864 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Costello, Richard
Izumi, Takateru
MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE
title MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE
title_full MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE
title_fullStr MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE
title_full_unstemmed MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE
title_short MEASUREMENT OF RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN ALBINO MICE : THE IMMUNE PHASE
title_sort measurement of resistance to experimental tuberculosis in albino mice : the immune phase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138908/
https://www.ncbi.nlm.nih.gov/pubmed/5133864
work_keys_str_mv AT costellorichard measurementofresistancetoexperimentaltuberculosisinalbinomicetheimmunephase
AT izumitakateru measurementofresistancetoexperimentaltuberculosisinalbinomicetheimmunephase

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