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ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS
By depletion of C3 from rabbits undergoing acute experimental immune complex disease with an anticomplementary factor in cobra venom, it has been possible to demonstrate that deposition of the complexes in arteries and glomeruli does not require the complement components reacting after C2. Immunolog...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1971
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138950/ https://www.ncbi.nlm.nih.gov/pubmed/4106804 |
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author | Henson, P. M. Cochrane, C. G. |
author_facet | Henson, P. M. Cochrane, C. G. |
author_sort | Henson, P. M. |
collection | PubMed |
description | By depletion of C3 from rabbits undergoing acute experimental immune complex disease with an anticomplementary factor in cobra venom, it has been possible to demonstrate that deposition of the complexes in arteries and glomeruli does not require the complement components reacting after C2. Immunological reactions, in which platelets release their vasoactive amines, have been examined in rabbits undergoing immune complex disease. A correlation was obtained between the presence of a complement-independent reaction which required blood leukocytes, antigen and platelets, the deposition of immune complexes, and the induction of glomerulonephritis. C3 depletion did, however, have a marked alleviating effect on the severity of the arterial lesions. Neutrophil accumulation and the subsequent necrotizing arteritis were prevented. In contrast, the character and severity of the glomerulonephritis was not altered by depletion of later-acting complement components. |
format | Text |
id | pubmed-2138950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1971 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21389502008-04-17 ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS Henson, P. M. Cochrane, C. G. J Exp Med Article By depletion of C3 from rabbits undergoing acute experimental immune complex disease with an anticomplementary factor in cobra venom, it has been possible to demonstrate that deposition of the complexes in arteries and glomeruli does not require the complement components reacting after C2. Immunological reactions, in which platelets release their vasoactive amines, have been examined in rabbits undergoing immune complex disease. A correlation was obtained between the presence of a complement-independent reaction which required blood leukocytes, antigen and platelets, the deposition of immune complexes, and the induction of glomerulonephritis. C3 depletion did, however, have a marked alleviating effect on the severity of the arterial lesions. Neutrophil accumulation and the subsequent necrotizing arteritis were prevented. In contrast, the character and severity of the glomerulonephritis was not altered by depletion of later-acting complement components. The Rockefeller University Press 1971-02-28 /pmc/articles/PMC2138950/ /pubmed/4106804 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Henson, P. M. Cochrane, C. G. ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS |
title | ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS |
title_full | ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS |
title_fullStr | ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS |
title_full_unstemmed | ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS |
title_short | ACUTE IMMUNE COMPLEX DISEASE IN RABBITS : THE ROLE OF COMPLEMENT AND OF A LEUKOCYTE-DEPENDENT RELEASE OF VASOACTIVE AMINES FROM PLATELETS |
title_sort | acute immune complex disease in rabbits : the role of complement and of a leukocyte-dependent release of vasoactive amines from platelets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138950/ https://www.ncbi.nlm.nih.gov/pubmed/4106804 |
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