SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE

The acquisition of a capacity to respond well to sheep erythrocytes in the presence of anti-SRBC antibody was taken as an indication of the presence of immunological memory. By the use of passive immunization, both the primary IgG plaque-forming cell response and the establishment of memory were abo...

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Detalles Bibliográficos
Autor principal: Axelrad, Michael A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138965/
https://www.ncbi.nlm.nih.gov/pubmed/4926208
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author Axelrad, Michael A.
author_facet Axelrad, Michael A.
author_sort Axelrad, Michael A.
collection PubMed
description The acquisition of a capacity to respond well to sheep erythrocytes in the presence of anti-SRBC antibody was taken as an indication of the presence of immunological memory. By the use of passive immunization, both the primary IgG plaque-forming cell response and the establishment of memory were abolished, despite occurrence of a full peak IgM PFC response. Evidence for regarding the aquisition of memory and the IgM PFC and IgG PFC responses as three separate processes was presented. Antibody on day 3 of the response to 1.5 x 10(8) SRBC abolished formation of memory; this effect was less if passive immunization was further delayed and absent by day 10.
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spelling pubmed-21389652008-04-17 SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE Axelrad, Michael A. J Exp Med Article The acquisition of a capacity to respond well to sheep erythrocytes in the presence of anti-SRBC antibody was taken as an indication of the presence of immunological memory. By the use of passive immunization, both the primary IgG plaque-forming cell response and the establishment of memory were abolished, despite occurrence of a full peak IgM PFC response. Evidence for regarding the aquisition of memory and the IgM PFC and IgG PFC responses as three separate processes was presented. Antibody on day 3 of the response to 1.5 x 10(8) SRBC abolished formation of memory; this effect was less if passive immunization was further delayed and absent by day 10. The Rockefeller University Press 1971-03-31 /pmc/articles/PMC2138965/ /pubmed/4926208 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Axelrad, Michael A.
SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE
title SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE
title_full SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE
title_fullStr SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE
title_full_unstemmed SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE
title_short SUPPRESSION OF MEMORY BY PASSIVE IMMUNIZATION LATE IN THE PRIMARY RESPONSE
title_sort suppression of memory by passive immunization late in the primary response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138965/
https://www.ncbi.nlm.nih.gov/pubmed/4926208
work_keys_str_mv AT axelradmichaela suppressionofmemorybypassiveimmunizationlateintheprimaryresponse

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