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PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION

The isoimmune response of fowl inoculated with RBC coated with antibody was investigated. Anti-B antiserum from a single animal was used to coat different donor type RBC. With each donor type RBC the immune response to the coated determinants is suppressed. Enhancement of the immune response to nonc...

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Detalles Bibliográficos
Autores principales: McBride, Raymond A., Schierman, Louis W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139002/
https://www.ncbi.nlm.nih.gov/pubmed/4106486
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author McBride, Raymond A.
Schierman, Louis W.
author_facet McBride, Raymond A.
Schierman, Louis W.
author_sort McBride, Raymond A.
collection PubMed
description The isoimmune response of fowl inoculated with RBC coated with antibody was investigated. Anti-B antiserum from a single animal was used to coat different donor type RBC. With each donor type RBC the immune response to the coated determinants is suppressed. Enhancement of the immune response to noncoated determinants occurs when they are products of an allelic gene or belong to a different blood group system. Coating some B antigen determinants suppresses the response to noncoated determinants of the same antigen, i.e., determinants which are products of the same B gene. Varying the quantity of passive antibody revealed that the degree of suppression and the degree of enhancement are negatively correlated. These findings support the concept that antibody-coated determinants function as carrier for noncoated determinants, provided a certain physical association exists between them. A further interpretation of these studies is that in certain situations an antibody to one antigen may interfere with events which lead to an immune response to a different antigen. The possibility, that the protection afforded by ABO incompatibility against Rh isoimmunization is because of a similar phenomenon, is discussed. A hypothesis is presented which states that where the immune response to certain antigens behaves as a dominantly inherited trait, and is associated with histocompatibility type, the nonresponder animals possess an antibody (perhaps cell bound) which interferes with the response to determinants for which it does not have specificity. Responders are assumed to lack this antibody because it has specificity for their major histocompatibility antigens.
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spelling pubmed-21390022008-04-17 PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION McBride, Raymond A. Schierman, Louis W. J Exp Med Article The isoimmune response of fowl inoculated with RBC coated with antibody was investigated. Anti-B antiserum from a single animal was used to coat different donor type RBC. With each donor type RBC the immune response to the coated determinants is suppressed. Enhancement of the immune response to noncoated determinants occurs when they are products of an allelic gene or belong to a different blood group system. Coating some B antigen determinants suppresses the response to noncoated determinants of the same antigen, i.e., determinants which are products of the same B gene. Varying the quantity of passive antibody revealed that the degree of suppression and the degree of enhancement are negatively correlated. These findings support the concept that antibody-coated determinants function as carrier for noncoated determinants, provided a certain physical association exists between them. A further interpretation of these studies is that in certain situations an antibody to one antigen may interfere with events which lead to an immune response to a different antigen. The possibility, that the protection afforded by ABO incompatibility against Rh isoimmunization is because of a similar phenomenon, is discussed. A hypothesis is presented which states that where the immune response to certain antigens behaves as a dominantly inherited trait, and is associated with histocompatibility type, the nonresponder animals possess an antibody (perhaps cell bound) which interferes with the response to determinants for which it does not have specificity. Responders are assumed to lack this antibody because it has specificity for their major histocompatibility antigens. The Rockefeller University Press 1971-10-01 /pmc/articles/PMC2139002/ /pubmed/4106486 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McBride, Raymond A.
Schierman, Louis W.
PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION
title PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION
title_full PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION
title_fullStr PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION
title_full_unstemmed PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION
title_short PASSIVE ANTIBODY AND THE IMMUNE RESPONSE : FACTORS WHICH DETERMINE ENHANCEMENT AND SUPPRESSION
title_sort passive antibody and the immune response : factors which determine enhancement and suppression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139002/
https://www.ncbi.nlm.nih.gov/pubmed/4106486
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