SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES

The heat-stable, homocytotropic antibody synthesized by guinea pigs to highly purified dextran has been studied by passive cutaneous anaphylaxis (PCA). Antibody arising in single guinea pigs was found to give PCA in some homologous recipients but not in others. Data are presented which indicate that...

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Detalles Bibliográficos
Autores principales: Battisto, Jack R., Budman, Daniel, Freedman, Robert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139047/
https://www.ncbi.nlm.nih.gov/pubmed/5559609
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author Battisto, Jack R.
Budman, Daniel
Freedman, Robert
author_facet Battisto, Jack R.
Budman, Daniel
Freedman, Robert
author_sort Battisto, Jack R.
collection PubMed
description The heat-stable, homocytotropic antibody synthesized by guinea pigs to highly purified dextran has been studied by passive cutaneous anaphylaxis (PCA). Antibody arising in single guinea pigs was found to give PCA in some homologous recipients but not in others. Data are presented which indicate that the antibodies are bound in the skin of some animals to a greater degree than in that of others. This suggests some type of variability, perhaps allotypic, in the Fc portion of these immunoglobulins which relates to specificities of the loci where Fc becomes fixed in skin.
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spelling pubmed-21390472008-04-17 SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES Battisto, Jack R. Budman, Daniel Freedman, Robert J Exp Med Article The heat-stable, homocytotropic antibody synthesized by guinea pigs to highly purified dextran has been studied by passive cutaneous anaphylaxis (PCA). Antibody arising in single guinea pigs was found to give PCA in some homologous recipients but not in others. Data are presented which indicate that the antibodies are bound in the skin of some animals to a greater degree than in that of others. This suggests some type of variability, perhaps allotypic, in the Fc portion of these immunoglobulins which relates to specificities of the loci where Fc becomes fixed in skin. The Rockefeller University Press 1971-08-01 /pmc/articles/PMC2139047/ /pubmed/5559609 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Battisto, Jack R.
Budman, Daniel
Freedman, Robert
SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES
title SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES
title_full SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES
title_fullStr SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES
title_full_unstemmed SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES
title_short SPECIFICITY OF FIXATION LOCI FOR HOMOCYTOTROPIC ANTIBODIES
title_sort specificity of fixation loci for homocytotropic antibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139047/
https://www.ncbi.nlm.nih.gov/pubmed/5559609
work_keys_str_mv AT battistojackr specificityoffixationlociforhomocytotropicantibodies
AT budmandaniel specificityoffixationlociforhomocytotropicantibodies
AT freedmanrobert specificityoffixationlociforhomocytotropicantibodies

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