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IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE
The sensitization of human lung with atopic serum is both time and temperature dependent. Highly purified IgE myeloma protein is capable of blocking sensitization of human lung with atopic serum whereas myeloma proteins of the IgG subgroups are inactive. Drugs capable of increasing cellular levels o...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1971
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139070/ https://www.ncbi.nlm.nih.gov/pubmed/19867362 |
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author | Orange, Robert P. Austen, W. Gerald Austen, K. Frank |
author_facet | Orange, Robert P. Austen, W. Gerald Austen, K. Frank |
author_sort | Orange, Robert P. |
collection | PubMed |
description | The sensitization of human lung with atopic serum is both time and temperature dependent. Highly purified IgE myeloma protein is capable of blocking sensitization of human lung with atopic serum whereas myeloma proteins of the IgG subgroups are inactive. Drugs capable of increasing cellular levels of CAMP such as β-adrenergic agents and methylxanthines inhibit the antigen-induced release of both histamine and SRS-A from human lung and these agents demonstrate synergism when used together. The β-adrenergic blocking agent, propranolol, prevents epinephrine-induced inhibition of the immunologic release of the mediators. Diethylcarbamazine also inhibits the antigen-induced release of histamine and SRS-A from human lung and a synergism between this drug and epinephrine is observed. Predominantly α-adrenergic stimulation achieved by combining propranolol with epinephrine or norepinephrine not only prevented the inhibitory activity of the sympathomimetic amines but also resulted in an enhanced release of histamine and SRS-A. These observations suggest that whereas increases in cellular levels of CAMP are inhibitory, decreases in cellular levels of CAMP enhance the antigen-induced release of the mediators. |
format | Text |
id | pubmed-2139070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1971 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21390702008-04-17 IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE Orange, Robert P. Austen, W. Gerald Austen, K. Frank J Exp Med Mediation of Immunological Injury The sensitization of human lung with atopic serum is both time and temperature dependent. Highly purified IgE myeloma protein is capable of blocking sensitization of human lung with atopic serum whereas myeloma proteins of the IgG subgroups are inactive. Drugs capable of increasing cellular levels of CAMP such as β-adrenergic agents and methylxanthines inhibit the antigen-induced release of both histamine and SRS-A from human lung and these agents demonstrate synergism when used together. The β-adrenergic blocking agent, propranolol, prevents epinephrine-induced inhibition of the immunologic release of the mediators. Diethylcarbamazine also inhibits the antigen-induced release of histamine and SRS-A from human lung and a synergism between this drug and epinephrine is observed. Predominantly α-adrenergic stimulation achieved by combining propranolol with epinephrine or norepinephrine not only prevented the inhibitory activity of the sympathomimetic amines but also resulted in an enhanced release of histamine and SRS-A. These observations suggest that whereas increases in cellular levels of CAMP are inhibitory, decreases in cellular levels of CAMP enhance the antigen-induced release of the mediators. The Rockefeller University Press 1971-09-01 /pmc/articles/PMC2139070/ /pubmed/19867362 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Mediation of Immunological Injury Orange, Robert P. Austen, W. Gerald Austen, K. Frank IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE |
title | IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE |
title_full | IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE |
title_fullStr | IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE |
title_full_unstemmed | IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE |
title_short | IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG : I. MODULATION BY AGENTS INFLUENCING CELLULAR LEVELS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE |
title_sort | immunological release of histamine and slow-reacting substance of anaphylaxis from human lung : i. modulation by agents influencing cellular levels of cyclic 3',5'-adenosine monophosphate |
topic | Mediation of Immunological Injury |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139070/ https://www.ncbi.nlm.nih.gov/pubmed/19867362 |
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