ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE

Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver fail...

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Detalles Bibliográficos
Autores principales: Wortis, Henry H., Nehlsen, Sandra, Owen, John J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139084/
https://www.ncbi.nlm.nih.gov/pubmed/15776569
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author Wortis, Henry H.
Nehlsen, Sandra
Owen, John J.
author_facet Wortis, Henry H.
Nehlsen, Sandra
Owen, John J.
author_sort Wortis, Henry H.
collection PubMed
description Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes.
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spelling pubmed-21390842008-04-17 ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE Wortis, Henry H. Nehlsen, Sandra Owen, John J. J Exp Med Article Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes. The Rockefeller University Press 1971-09-01 /pmc/articles/PMC2139084/ /pubmed/15776569 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wortis, Henry H.
Nehlsen, Sandra
Owen, John J.
ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE
title ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE
title_full ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE
title_fullStr ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE
title_full_unstemmed ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE
title_short ABNORMAL DEVELOPMENT OF THE THYMUS IN "NUDE" MICE
title_sort abnormal development of the thymus in "nude" mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139084/
https://www.ncbi.nlm.nih.gov/pubmed/15776569
work_keys_str_mv AT wortishenryh abnormaldevelopmentofthethymusinnudemice
AT nehlsensandra abnormaldevelopmentofthethymusinnudemice
AT owenjohnj abnormaldevelopmentofthethymusinnudemice

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