THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS

A single injection of ε,DNP-Lys(7–10) can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritone...

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Detalles Bibliográficos
Autores principales: Schlossman, Stuart F., Levin, Howard A., Rocklin, Ross E., David, John R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139091/
https://www.ncbi.nlm.nih.gov/pubmed/15776572
Descripción
Sumario:A single injection of ε,DNP-Lys(7–10) can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritoneal exudates of those animals. In contrast, it was intriguing to find that lymph node lymphocytes from such animals responded normally in the antigen-induced thymidine incorporation assay. These studies demonstrate a compartmentalization of antigen-reactive lymphocytes in desensitized animals which may account for the short-lived nature of this phenomenon.

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