THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS

A single injection of ε,DNP-Lys(7–10) can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritone...

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Detalles Bibliográficos
Autores principales: Schlossman, Stuart F., Levin, Howard A., Rocklin, Ross E., David, John R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139091/
https://www.ncbi.nlm.nih.gov/pubmed/15776572
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author Schlossman, Stuart F.
Levin, Howard A.
Rocklin, Ross E.
David, John R.
author_facet Schlossman, Stuart F.
Levin, Howard A.
Rocklin, Ross E.
David, John R.
author_sort Schlossman, Stuart F.
collection PubMed
description A single injection of ε,DNP-Lys(7–10) can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritoneal exudates of those animals. In contrast, it was intriguing to find that lymph node lymphocytes from such animals responded normally in the antigen-induced thymidine incorporation assay. These studies demonstrate a compartmentalization of antigen-reactive lymphocytes in desensitized animals which may account for the short-lived nature of this phenomenon.
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spelling pubmed-21390912008-04-17 THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS Schlossman, Stuart F. Levin, Howard A. Rocklin, Ross E. David, John R. J Exp Med Article A single injection of ε,DNP-Lys(7–10) can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritoneal exudates of those animals. In contrast, it was intriguing to find that lymph node lymphocytes from such animals responded normally in the antigen-induced thymidine incorporation assay. These studies demonstrate a compartmentalization of antigen-reactive lymphocytes in desensitized animals which may account for the short-lived nature of this phenomenon. The Rockefeller University Press 1971-09-01 /pmc/articles/PMC2139091/ /pubmed/15776572 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Schlossman, Stuart F.
Levin, Howard A.
Rocklin, Ross E.
David, John R.
THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS
title THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS
title_full THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS
title_fullStr THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS
title_full_unstemmed THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS
title_short THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS
title_sort compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139091/
https://www.ncbi.nlm.nih.gov/pubmed/15776572
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