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SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE

The ability of guinea pigs to make immune responses to the random linear copolymer of L-glutamic acid and L-alanine, GA, and to L-glutamic acid and L-tyrosine, GT, is each controlled by a different immune response gene. On the other hand, the random linear terpolymer of L-glutamic acid, L-alanine, a...

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Detalles Bibliográficos
Autores principales: Bluestein, Harry G., Green, Ira, Maurer, Paul H., Benacerraf, Baruj
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139119/
https://www.ncbi.nlm.nih.gov/pubmed/5009706
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author Bluestein, Harry G.
Green, Ira
Maurer, Paul H.
Benacerraf, Baruj
author_facet Bluestein, Harry G.
Green, Ira
Maurer, Paul H.
Benacerraf, Baruj
author_sort Bluestein, Harry G.
collection PubMed
description The ability of guinea pigs to make immune responses to the random linear copolymer of L-glutamic acid and L-alanine, GA, and to L-glutamic acid and L-tyrosine, GT, is each controlled by a different immune response gene. On the other hand, the random linear terpolymer of L-glutamic acid, L-alanine, and L-tyrosine, GAT, which contains both GA and GT antigenic determinants, is immunogenic in all guinea pigs. After GAT immunization, all animals develop delayed hvpersensitivity and serum antibody specific for GAT. However, only those guinea pigs possessing the GA immune response gene demonstrate cross-reactive delayed hypersensitivity when challenged with GA. In addition, the anti-GAT antisera produced by those animals having the GA gene contain cross-reacting anti-GA antibodies. The sera from guinea pigs lacking the GA gene have no anti-GA antibody activity. Thus, we have demonstrated that a specific immune response gene controlling responsiveness to a "simple" antigen can determine the specificity of both cellular and humoral immune responses to a more complex antigen.
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spelling pubmed-21391192008-04-17 SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE Bluestein, Harry G. Green, Ira Maurer, Paul H. Benacerraf, Baruj J Exp Med Article The ability of guinea pigs to make immune responses to the random linear copolymer of L-glutamic acid and L-alanine, GA, and to L-glutamic acid and L-tyrosine, GT, is each controlled by a different immune response gene. On the other hand, the random linear terpolymer of L-glutamic acid, L-alanine, and L-tyrosine, GAT, which contains both GA and GT antigenic determinants, is immunogenic in all guinea pigs. After GAT immunization, all animals develop delayed hvpersensitivity and serum antibody specific for GAT. However, only those guinea pigs possessing the GA immune response gene demonstrate cross-reactive delayed hypersensitivity when challenged with GA. In addition, the anti-GAT antisera produced by those animals having the GA gene contain cross-reacting anti-GA antibodies. The sera from guinea pigs lacking the GA gene have no anti-GA antibody activity. Thus, we have demonstrated that a specific immune response gene controlling responsiveness to a "simple" antigen can determine the specificity of both cellular and humoral immune responses to a more complex antigen. The Rockefeller University Press 1972-01-01 /pmc/articles/PMC2139119/ /pubmed/5009706 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bluestein, Harry G.
Green, Ira
Maurer, Paul H.
Benacerraf, Baruj
SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE
title SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE
title_full SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE
title_fullStr SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE
title_full_unstemmed SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE
title_short SPECIFIC IMMUNE RESPONSE GENES OF THE GUINEA PIG : V. INFLUENCE OF THE GA AND GT IMMUNE RESPONSE GENES ON THE SPECIFICITY OF CELLULAR AND HUMORAL IMMUNE RESPONSES TO A TERPOLYMER OFL-GLUTAMIC ACID, L-ALANINE, ANDL-TYROSINE
title_sort specific immune response genes of the guinea pig : v. influence of the ga and gt immune response genes on the specificity of cellular and humoral immune responses to a terpolymer ofl-glutamic acid, l-alanine, andl-tyrosine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139119/
https://www.ncbi.nlm.nih.gov/pubmed/5009706
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