CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS

Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover,...

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Detalles Bibliográficos
Autores principales: Berke, Gideon, Levey, Raphael H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139151/
https://www.ncbi.nlm.nih.gov/pubmed/4622914
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author Berke, Gideon
Levey, Raphael H.
author_facet Berke, Gideon
Levey, Raphael H.
author_sort Berke, Gideon
collection PubMed
description Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover, the adsorbed immunoreactive cells can be recovered specifically and are subsequently efficient in inhibiting tumor growth in vivo and in killing tumor cells in vitro. Further evidence is presented for the suggestion that the destruction of target cells in vitro by sensitized lymphoid cells is truly representative of the mode of destruction of grafted cells in vivo.
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spelling pubmed-21391512008-04-17 CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS Berke, Gideon Levey, Raphael H. J Exp Med Article Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover, the adsorbed immunoreactive cells can be recovered specifically and are subsequently efficient in inhibiting tumor growth in vivo and in killing tumor cells in vitro. Further evidence is presented for the suggestion that the destruction of target cells in vitro by sensitized lymphoid cells is truly representative of the mode of destruction of grafted cells in vivo. The Rockefeller University Press 1972-03-31 /pmc/articles/PMC2139151/ /pubmed/4622914 Text en Copyright © 1972 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Berke, Gideon
Levey, Raphael H.
CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS
title CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS
title_full CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS
title_fullStr CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS
title_full_unstemmed CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS
title_short CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY : SPECIFIC IN VITRO DELETION AND RECOVERY OF MOUSE LYMPHOID CELLS SENSITIZED AGAINST ALLOGENEIC TUMORS
title_sort cellular immunoabsorbents in transplantation immunity : specific in vitro deletion and recovery of mouse lymphoid cells sensitized against allogeneic tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139151/
https://www.ncbi.nlm.nih.gov/pubmed/4622914
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AT leveyraphaelh cellularimmunoabsorbentsintransplantationimmunityspecificinvitrodeletionandrecoveryofmouselymphoidcellssensitizedagainstallogeneictumors

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