LYMPHOID CELLS IN DELAYED HYPERSENSITIVITY : III. THE INFLUENCE OF X-IRRADIATION ON PASSIVE TRANSFER AND ON IN VITRO PRODUCTION OF SOLUBLE MEDIATORS

X-irradiation up to 480 R does not inhibit either adoptive transfer of delayed hypersensitivity or production in vitro of soluble mediators, such as migration-inhibitory factor (MIF). Above that dosage and as high as 3000 R, adoptive transfer is inhibited, but production of MIF is not. An increase i...

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Detalles Bibliográficos
Autores principales: Salvin, S. B., Nishio, J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139154/
https://www.ncbi.nlm.nih.gov/pubmed/5018056
Descripción
Sumario:X-irradiation up to 480 R does not inhibit either adoptive transfer of delayed hypersensitivity or production in vitro of soluble mediators, such as migration-inhibitory factor (MIF). Above that dosage and as high as 3000 R, adoptive transfer is inhibited, but production of MIF is not. An increase in skin response occurred when 24–48 hr were allowed to elapse after intravenous transfer and before skin testing. Treatment of recipients with colchicine at the time of adoptive transfer inhibited the development of a skin reaction to specific antigen.

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