CELL SURFACE IMMUNOGLOBULIN : IV. DISTRIBUTION AMONG THYMOCYTES, BONE MARROW CELLS, AND THEIR DERIVED POPULATIONS

Thymocytes, bone marrow cells, and their derived T and B cell populations were examined for the presence of Ig by the cell surface radioiodination technique. Both IgM and IgG were identified on bone marrow cells. Thymocytes and T cells had no detectable cell surface Ig. Radiolabeling of mixtures of...

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Detalles Bibliográficos
Autores principales: Vitetta, Ellen S., Bianco, Celso, Nussenzweig, Victor, Uhr, Jonathan W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1972
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139194/
https://www.ncbi.nlm.nih.gov/pubmed/5064226
Descripción
Sumario:Thymocytes, bone marrow cells, and their derived T and B cell populations were examined for the presence of Ig by the cell surface radioiodination technique. Both IgM and IgG were identified on bone marrow cells. Thymocytes and T cells had no detectable cell surface Ig. Radiolabeling of mixtures of B cells and thymocytes suggest that the method may detect as little as 250 molecules of Ig per cell. Based on these findings, we suggest that the T cell receptor for antigen is not a conventional tetrameric Ig.

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